微透析技术在药代动力学领域应用的文献计量学与可视化分析  

Bibliometrics and visual analysis of microdialysis technology in the field of pharmacokinetics

作　　者：苏奕晨 曹泽锟 谷俊远 李昕 邓长辉 SU Yichen;CAO Zekun;GU Junyuan;LI Xin;DENG Changhui(Hunan University of Chinese Medicine,Changsha,Hunan,410208;the Third Hospital of Changsha of Hunan Province,Changsha,Hunan,410015;Hunan Provincial Key Laboratory of Antimicrobial Resistant Microorganism,Changsha,Hunan,410015)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南省长沙市第三医院,湖南长沙410015 [3]抗耐药微生物药物湖南省重点实验室,湖南长沙410015

出　　处：《实用临床医药杂志》2023年第20期99-104,共6页Journal of Clinical Medicine in Practice

基　　金：抗耐药微生物药物湖南省重点实验室项目(2023TP1013)。

摘　　要：目的对Web of Science(WOS)数据库中关于微透析技术在药代动力学领域的研究进行文献计量学与可视化分析。方法以发文年份、国家和主题术语、关键词、高频引用文献等情况为指标,统计分析WOS核心合集中微透析技术在药代动力学领域的相关文献。结果共纳入604篇文献。2013—2015年,每年发文量均在55篇。2016—2023年,每年发文量稳定在60篇左右。近10年累计发文量呈线性增长。发文量最多的国家是中国(193篇)。2013—2018年"brain microdialysis""mice""Parkinson disease"等关键词出现较多。2019—2023年"morbidly obese""children""cerebral microdialysis""bone""surgical site infection""antibiotic prophylaxis"等关键词出现较多。结论目前,微透析技术在基础药代动力学领域应用广泛,未来其可能在外周组织给药、药物浓度监测及神经危重症监护等临床实践中发挥重要作用。Objective To implement metrological and visual analysis for literatures related to microdialysis technology in pharmacokinetic field in Web of Science database(WOS).Methods The literature related to microdialysis technology in the field of pharmacokinetics in the core collection of WOS was analyzed,with the year of publication,country as well as subject terms,keywords and frequently cited references as indicators.Results A total of 604 articles were included.From 2013 to 2015,the number of publications per year was 55.From 2016 to 2023,the number of publications per year stabilized at about 60.In the past 10 years,the cumulative number of published documents had shown a linear growth.The country with the highest number of articles was China(193 articles).From 2013 to 2018,the most common keywords were"brain microdialysis""mice"and"Parkinson disease",etc.From 2019 to 2023,the most common keywords were"morbidly obese""children""cerebral microdialysis""bone""surgical site infection"and"antibiotic"prophylaxis",etc.Conclusion At present,microdialysis technology is widely used in the field of basic pharmacokinetics,and it may play an important role in clinical practice such as peripheral tissue delivery,drug concentration monitoring and neurocritical care in the future.

关 键 词：微透析 药代动力学 脑 抗感染 文献计量学 可视化 

分 类 号：R969.1[医药卫生—药理学] R965.2[医药卫生—药学]