基于数据挖掘分析现代中药复方治疗癌性骨痛的组方规律  

Medication Rule of Modern Traditional Chinese Medicine Compound Prescriptions for the Treatment of Cancer-induced Bone Pain Based on Data Mining

作　　者：张庆林 侯丽[1] 刘丽星 李淏 常金圆 冯利[2] ZHANG Qinglin;HOU Li;LIU Lixing;LI Hao;CHANG Jinyuan;FENG Li(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100007,China;National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital of Chinese Academy of Medical Sciences,Beijing 100021,China)

机构地区：[1]北京中医药大学东直门医院,北京100007 [2]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院肿瘤医院,北京100021

出　　处：《世界中医药》2023年第19期2815-2819,共5页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81873283);首都卫生发展科研专项项目(首发2020-2-4026)。

摘　　要：目的:基于数据挖掘技术分析中药复方治疗癌性骨痛(CIBP)的组方规律。方法:检索4大中文数据库自建库至2021年12月31日中药复方治疗骨癌痛的临床研究,筛选经研究证实有效的中药复方,并对有效复方所涉药味进行频次、性味归经、功效统计、关联规则分析、聚类分析及复杂网络可视化。结果:最终纳入62项随机对照试验研究,4 863例患者,其中观察组2 413例,对照组2 450例。涉及62首中药复方,应用中药139味,总频次715次,性味以甘温为最,主归肝、肾、脾三经,功效以补虚为主,活血化瘀次之。关联规则和复杂网络提示“熟地黄→骨碎补”关联性最强,聚类分析可将高频药物分为6类。结论:中药复方治疗骨癌痛以补益肝肾、活血通络为核心,“骨碎补→熟地黄”为治疗骨癌痛的核心药对,体现了中药复方治疗骨癌痛攻补兼施、标本兼顾的特点。Objective:To analyze the medication law of traditional Chinese medicine(TCM)compound prescriptions for the treatment of cancer-induced bone pain(CIBP)based on data mining.Methods:The clinical studies on the treatment of CIBP by TCM compound prescriptions were retrieved from four Chinese databases from the inception of the databases to December 31,2021.The effective TCM compound prescriptions were screened,and the frequency,properties,tastes,meridian tropism,and efficacy of the involved herbal medicines were analyzed.Association rule analysis,cluster analysis,and complex network visualization were conducted.Results:A total of 62 randomized controlled trials(RCTs)were obtained,including 4863 patients,2413 in the experimental group and 2450 in the control group.There were 62 TCM compound prescriptions,involving 139 herbal medicines,with a total frequency of 715.They were mostly pungent and warm and acted on the liver,kidney,and spleen,with the main effects of restoring qi,followed by activating blood and resolving stasis.The association rules and complex network suggested that“Radix Rhemanniae Praeparata→Rhizoma Drynariae”had the strongest correlation,and the high-frequency herbal medicines were divided into six categories by cluster analysis.Conclusion:Tonifying and replenishing the liver and kidney,activating blood and dredging meridians are the priorities in the treatment of CIBP by TCM compound prescriptions,and“Radix Rhemanniae Praeparata→Rhizoma Drynariae”was the core combination,which reflects the characteristics of reinforcing healthy qi and eliminating pathogenic factor as well as simultaneous treatment of the symptoms and root cause.

关 键 词：骨癌痛 骨转移 癌性疼痛 中药复方 组方规律 熟地黄 骨碎补 数据挖掘 

分 类 号：R273[医药卫生—中西医结合] R259[医药卫生—中医肿瘤科]