西格列汀治疗2型糖尿病合并急性脑梗死的疗效及其对患者睡眠质量的影响  

Efficacy of Sitagliptin in the Treatment of Type 2 Diabetes Mellitus Com⁃bined with Acute Cerebral Infarction and Its Effect on Patients' SleepQuality

作　　者：陈志聪 梁晓慧 徐江涛 吴亚东 CHEN Zhicong;LIANG Xiaohui;XU Jiangtao;WU Yadong(Department of Neurology,Xiamen Hongai Hospital Affiliated to Fujian Medical University,Xiamen,Fujian Province,361000 China)

机构地区：[1]福建医科大学附属厦门弘爱医院神经内科,福建厦门361000

出　　处：《糖尿病新世界》2023年第19期26-29,共4页Diabetes New World Magazine

基　　金：2020年厦门市医疗卫生指导性项目(3502Z20209061)。

摘　　要：目的研讨西格列汀治疗2型糖尿病合并急性脑梗死的疗效及其对患者睡眠质量的影响。方法选择2022年4月—2023年4月福建医科大学附属厦门弘爱医院收入的80例2型糖尿病合并急性脑梗死患者为研究对象,按随机数表法分成两组,各40例。两组均予以常规治疗,其中对照组给予格列美脲治疗,观察组加用西格列汀治疗,比较两组治疗效果以及对睡眠质量的影响。结果观察组治疗总有效率为97.50%,高于对照组的85.00%,差异有统计学意义(P<0.05)。治疗后,观察组空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2-hour postprandial blood glucose,2 hPG)、糖化血红蛋白(glycated hemoglobin,HbA1c)、美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)评分低于对照组,差异有统计学意义(P<0.05)。观察组用药不良反应总发生率为7.50%与对照组的5.00%比较,差异无统计学意义(P>0.05)。结论西格列汀治疗2型糖尿病合并急性脑梗死疗效佳,能改善血糖指标,减轻神经功能受损程度,提高睡眠质量,用药安全性高。Objective To investigate the efficacy of sitagliptin in the treatment of type 2 diabetes mellitus combined with acute cerebral infarction and its effect on patients'sleep quality.Methods A total of 80 patients with type 2 dia-betes mellitus complicated with acute cerebral infarction from Xiamen Hongai Hospital affiliated to Fujian Medical University from April 2022 to April 2023 were selected as the study objects and divided into two groups according to random number table method,with 40 patients in each group.The two groups were given routine treatment,the control group was given glimepiride treatment,the observation group was given sitagliptin treatment,the treatment effect and the influence on sleep quality of the two groups were compared.Results The total effective rate of the observation group was 97.50%,which was higher than that of the control group 85.00%,and the difference was statistically signifi-cant(P<0.05).After treatment,the fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 hPG),glycated hemoglobin(HbA1c),and National Institute of Health Stroke Scale(NIHSS)scores of the observation group were sig-nificantly lower than those of the control group,and the difference was statistically significant(P<0.05).After treat-ment,the Pittsburgh Sleep Quality Index(PSQI)score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse drug reactions in the ob-servation group was 7.50%compared with 5.00%in the control group,and the difference was not statistically signifi-cant(P>0.05).Conclusion Sigliptin has a good therapeutic effect on type 2 diabetes patients with acute cerebral infarc-tion.It can improve blood glucose indicators,reduce the degree of neurological impairment,improve sleep quality,and has high drug safety.

关 键 词：2型糖尿病 急性脑梗死 西格列汀 睡眠质量 

分 类 号：R977[医药卫生—药品]