甘精胰岛素联合阿卡波糖对老年人2型糖尿病的应用价值分析  

Application Value Analysis of Insulin Glargine Combined with Acarbosein Elderly Patients with Type 2 Diabetes Mellitus

作　　者：石磊 陈吉业 吕伟东 SHI Lei;CHEN Jiye;LYU Weidong(Department of Geriatrics,Mengyin County People's Hospital,Linyi,Shandong Province,276200 China)

机构地区：[1]蒙阴县人民医院老年病科,山东临沂276200

出　　处：《糖尿病新世界》2023年第19期99-102,共4页Diabetes New World Magazine

摘　　要：目的评价老年2型糖尿病患者以甘精胰岛素与阿卡波糖共同实施治疗的临床价值。方法选取2021年3月—2023年3月蒙阴县人民医院收治的86例2型糖尿病老年患者,依据随机数表划分两组,每组43例,对照组以甘精胰岛素实施治疗,研究组以甘精胰岛素、阿卡波糖共同治疗,对比两组患者疗效、血糖和肠道激素指标、不良反应发生情况。结果治疗后,研究组临床治疗总有效率为95.35%优于对照组的79.06%,差异有统计学意义(P<0.05);研究组的空腹血糖、糖化血红蛋白、餐后2 h血糖指标低于对照组,差异有统计学意义(P<0.05);研究组患者的空腹C肽、胰升血糖素样肽-1指标高于对照组,而血清抑胃肽指标低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为6.97%与对照组的9.30%比较,差异无统计学意义(P>0.05)。结论甘精胰岛素、阿卡波糖对2型糖尿病治疗能够增强临床疗效,能够使其血糖指标得到有效改善,降低不良反应发生率。Objective To evaluate the clinical value of insulin glargine and acarbose combined therapy in elderly pa-tients with type 2 diabetes mellitus.Methods 86 elderly patients with type 2 diabetes treated in Mengyin County People's Hospital from March 2021 to March 2023 were selected.According to the random number table,the patients were divided into two groups,with 43 patients in each group.The control group was treated with insulin glargine,while the study group was treated with insulin glargine and acarbose.The efficacy,blood glucose and intestinal hor-mone indexes and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the study group 95.35%was better than that of the control group 79.06%,and the difference was statistically significant(P<0.05).Fasting plasma-glucose,glycated hemoglobin and 2 h postprandial blood glucose in the study group were lower than those in the control group,the difference was statistically significant(P<0.05).The fasting C-peptide and glucagon-like peptide-1 indexes in the study group were higher than those in the control group,but the serum gastric inhibitory peptide indexes were lower than those in the control group,the difference was statistically sig-nificant(P<0.05).There was no statistical significance in adverse reaction rate of 6.97%in the study group and 9.30%in the control group(P>0.05).Conclusion Insulin glargine and acarbose can enhance the clinical efficacy,effectively improve the blood glucose index,and greatly reduce the incidence of adverse reactions in the treatment of type 2 dia-betes mellitus.

关 键 词：甘精胰岛素 阿卡波糖 2型糖尿病 治疗效果 

分 类 号：R587.1[医药卫生—内分泌]