胰岛素结合二甲双胍治疗儿童1型糖尿病的效果分析  

Analysis of the Effect of Insulin Combined with Metformin in the Treat⁃ment of Type 1 Diabetes Mellitus in Children

作　　者：刘亚萍 LIU Yaping(Department of Pediatrics,Linyi Central Hospital,Linyi,Shandong Province,276400 China)

机构地区：[1]临沂市中心医院儿科,山东临沂276400

出　　处：《糖尿病新世界》2023年第19期111-113,141,共4页Diabetes New World Magazine

摘　　要：目的探讨对儿童1型糖尿病患儿采用胰岛素+二甲双胍完成治疗后的临床效果。方法选取2020年5月—2022年12月临沂市中心医院收治的60例儿童1型糖尿病患儿作为研究对象,根据随机数表法分为对照组和研究组,各30例。对照组单纯施以胰岛素治疗,研究组在对照组基础上加用二甲双胍治疗。对比两组患儿的血糖控制情况、住院时间、每日胰岛素用量、不良反应发生率。结果治疗前,研究组患儿的血糖控制情况与对照组比较,差异无统计学意义(P>0.05);治疗后,研究组患儿的糖化血红蛋白水平、空腹血糖水平以及血糖波动幅度降低程度较对照组更明显,差异有统计学意义(P<0.05)。研究组患儿住院时间与对照组比较,差异无统计学意义(P>0.05);研究组患儿每日胰岛素用量减少程度较对照组明显,差异有统计学意义(P<0.05)。研究组患儿酮症酸中毒发生率与对照组比较,差异无统计学意义(P>0.05);研究组患儿低血糖事件发生率明显低于对照组,差异有统计学意义(P<0.05)。结论临床对儿童1型糖尿病患儿在治疗期间,胰岛素+二甲双胍药物联合应用,对于患儿血糖水平控制以及低血糖事件发生率的降低,可以获得显著效果,提高疗效。Objective To explore the clinical effect of insulin+metformin after completing the treatment of pediatric type 1 diabetes mellitus patients.Methods 60 children with type 1 diabetes admitted to Linyi Central Hospital from May 2020 to December 2022 were selected as the study objects,and were divided into control group and study group according to random number table method,with 30 cases in each group.The control group was treated with insulin alone,and the study group was treated with metformin in addition to the control group.Blood glucose control,length of hospital stay,daily insulin dosage and incidence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in blood glucose control between the study group and the control group(P>0.05).After treatment,the gglycosylated hemoglobin,fasting plasma glucose and fluctuation range of blood glucose in the study group were reduced more significantly than those in the control group,and the dif-ference was statistically significant(P<0.05).There was no statistically significant difference in hospitalization time be-tween the study group and the control group(P>0.05).The decrease of daily insulin dosage in the study group was sig-nificantly higher than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of ketoacidosis between the study group and the control group(P>0.05).The incidence of hypoglycemia events in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion During the treatment of pediatric patients with type 1 diabetes mellitus,the combined application of insulin and metformin can achieve significant results in control-ling blood glucose levels and reducing the incidence of hypoglycemic events and improve the efficacy of treatment.

关 键 词：胰岛素 二甲双胍 儿童1型糖尿病 应用效果设置 

分 类 号：R4[医药卫生—临床医学]