利格列汀片联合羟苯磺酸钙胶囊治疗糖尿病肾病的临床研究  

Clinical Study of Linagliptin Tablets Combined with Calcium DobesilateCapsules in the Treatment of Diabetic Nephropathy

作　　者：王晶[1] 程莉[1] 章晓良[1] WANG Jing;CHENG Li;ZHANG Xiaoiang(Department of Nephrology,the 910th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force,Quanzhou,Fujian Province,362000 China)

机构地区：[1]中国人民解放军联勤保障部队第九一〇医院肾内科,福建泉州362000

出　　处：《糖尿病新世界》2023年第19期168-171,共4页Diabetes New World Magazine

摘　　要：目的探讨利格列汀片联合羟苯磺酸钙胶囊治疗糖尿病肾病的临床价值。方法回顾性分析2019年5月—2022年5月中国人民解放军联勤保障部队第九一〇医院肾内科收治的60例糖尿病肾病患者的临床资料,按照入院先后顺序进编号并分组,前30例纳入对照组,常规行血糖、血压控制,运用盐酸贝那普利降低血压、减轻心脏和肾脏负担,从而保护肾脏功能等基础治疗;剩余30例纳入联合组,在常规基础治疗上使用利格列汀片联合羟苯磺酸钙胶囊联合治疗。对比两组的血糖、血脂情况,肾功能各项指标改善情况。结果治疗后,联合组血糖、血脂控制效果优于对照组,差异有统计学意义(P<0.05);治疗后,联合组血肌酐、尿素氮、蛋白尿排泄率、肾小球过滤率均低于对照组,差异有统计学意义(P<0.05)。结论糖尿病肾病在常规控糖控脂基础上使用利格列汀片联合羟苯磺酸钙胶囊进行药物联合治疗可增强血糖、血脂控制效果,同时联合用药下可对肾功能、疾病的治疗以及预后产生积极影响。Objective To investigate the clinical value of ligagliptin tablets combined with calcium isobenesulfate cap-sules in the treatment of diabetic nephropathy.Methods Clinical data of 60 patients with diabetic nephropathy admit-ted to the Renal Department of 901 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force from May 2019 to May 2022 were retrospectively analyzed,numbered and grouped according to the order of admis-sion.The first 30 patients were included in the control group,which received routine blood glucose and blood pressure control,and Benazepril hydrochloride was used to reduce blood pressure and relieve the burden on the heart and kid-ney,to protect kidney function and other basic treatment.The remaining 30 cases were included in the combination group,which was treated with ligagliptin tablets combined with calcium isobenesulfonate capsules in addition to con-ventional basic treatment.The improvement of blood glucose,blood lipids and renal function indexes were compared between the two groups.Results After treatment,the control effect of blood glucose and blood lipid in combination group was better than that in control group,and the difference was statistically significant(P<0.05).After treatment,serum creatinine,urea nitrogen,albuminuria excretion rate and glomerular filtration rate in combined group were lower than those in control group,the difference was statistically significant(P<0.05).Conclusion On the basis of con-ventional glycemic and lipid control,the combination treatment of liagliptin tablets combined with calcium isobenesul-fate capsules for diabetic nephropathy can enhance the control effect of blood sugar and lipid,and can have a positive impact on renal function,disease treatment and prognosis.

关 键 词：利格列汀片 羟苯磺酸钙胶囊 糖尿病肾病 临床效果 

分 类 号：R4[医药卫生—临床医学]