甲巯咪唑治疗妊娠合并甲亢对妊娠结局和免疫功能的影响  

Effect of Methimazole Treatment of Combined Hyperthyroidism in Pregnancy on the Outcome of Pregnancy and Immune Function

作　　者：李娜 LI Na(Department of Laboratory,Beijing Shunyi District Maternal and Child Health Hospital,Beijing,101300 China)

机构地区：[1]北京市顺义区妇幼保健院检验科,北京101300

出　　处：《系统医学》2023年第17期171-174,共4页Systems Medicine

摘　　要：目的探讨甲巯咪唑治疗妊娠合并甲亢对妊娠结局和免疫功能的影响。方法选取2019年1月—2023年4月北京市顺义区妇幼保健院收治的150例妊娠合并甲亢患者为研究对象,将患者根据入院顺序进行分组,每组75例。其中对照组采用丙基硫氧嘧啶进行治疗,观察组实施甲巯咪唑进行治疗,比较两组治疗效果。结果观察组总有效率为98.67%,高于对照组的89.33%,差异有统计学意义(χ^(2)=4.255,P<0.05)。治疗后,观察组的游离甲状腺原氨酸、游离四碘甲状腺原氨酸低于对照组,促甲状腺素高于对照组,差异有统计学意义(P<0.05);治疗后,观察组的CD3^(+)、CD4^(+)高于对照组,CD8^(+)低于对照组,差异有统计学意义(P<0.05);观察组的不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。结论甲巯咪唑治疗妊娠合并甲亢的效果较为显著,可以改善患者的甲状腺功能以及免疫功能,减少不良妊娠结局发生率。Objective To investigate the effects of methimazole treatment of combined hyperthyroidism in pregnancy on the outcome of pregnancy and immune function.Methods A total of 150 pregnant patients with hyperthyroidism ad-mitted to Shunyi District Maternal and Child Health Hospital of Beijing from January 2019 to April 2023 were se-lected as the study subjects,and the patients were divided into groups according to the order of admission,with 75 cases in each group.The control group was treated with propyl thiouracil and the observation group was treated with methimazole.The therapeutic effect of the two groups was compared.Results The total effective rate of the observation group was 98.67%,which was higher than that of the control group(89.33%),the difference was statistically signifi-cant(χ^(2)=4.255,P<0.05).After treatment,the levels of free thyronine and free tetraiodothyronine in observation group were lower than those in control group,and the levels of thyrotropin in control group were higher,the difference was statistically significant(P<0.05).After treatment,CD3^(+)and CD4^(+)in observation group were higher than those in con-trol group,and CD8^(+)was lower than those in control group,the difference was statistically significant(P<0.05).The in-cidence of adverse pregnancy outcome in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The effect of methimazole in the treatment of combined hyperthy-roidism in pregnancy is more significant,which can improve the patient's thyroid function as well as immune function and reduce the incidence of adverse pregnancy outcomes.

关 键 词：妊娠合并甲亢 甲巯咪唑 妊娠结局 甲状腺功能 免疫功能 

分 类 号：R581[医药卫生—内分泌]