血清BNP、降钙素、D-二聚体联合检测对急性心力衰竭患者短期不良心血管事件的预测价值  

Predictive Value of Combined Detection of Serum BNP,Calcitonin and D-Dimer for Short-Term Adverse Cardiovascular Events in Patients with Acute Heart Failure

作　　者：余小萍[1] 苏永华[1] 薛丽莉[1] Yu Xiaoping(Department of Clinical Laboratory,Tongji Rehabilitation Hospital,Foshan First People’s Hospital,Foshan 528000)

机构地区：[1]佛山市第一人民医院同济康复医院检验科,广东佛山528000

出　　处：《黑龙江医药》2023年第5期1020-1023,共4页Heilongjiang Medicine journal

基　　金：佛山市卫生健康局医学科研课题立项(项目编号:20220368)。

摘　　要：目的:探讨血清B型脑利钠肽(BNP)、降钙素(PCT)、D-二聚体(D-D)联合检测对急性心力衰竭患者短期不良心血管事件(MACE)的预测价值。方法:选取我院2022年1月—2022年10月收治的60例急性心力衰竭患者,随访6个月后根据是否出现心源性死亡和/或因心力衰竭而再住院将患者分为非MACE组30例,MACE组30例。检测两组血清BNP、PCT及D-D水平,并收集两组患者的基本资料,使用多因素logistic回归分析,并进行受试者工作特征(ROC)曲线分析诊断效能。结果:MACE组血清BNP、PCT及D-D水平高于非MACE组(P<0.05);MACE组与非MACE组的年龄、LVEF、LVEDd、E/A经比较差异具有统计学意义(P<0.05);logistic回归分析结果显示,血清BNP、PCT及D-D水平是急性心力衰竭短期发生MACE的独立危险因素(P<0.05)。联合检测的AUC、灵敏度、特异度及准确度分别为95.6、90.00%、93.33%、91.67%,高于单一BNP、PCT、D-D的AUC、灵敏度、特异度及准确度。结论:BNP、PCT、D-D联合检测及实时监测可作为对急性心力衰竭患者短期不良心血管事件的预测指标,对预防短期不良心血管事件具有重要意义。Objective:To investigate the predictive value of serum B-type brain natriuretic peptide(BNP),calcitonin(PCT)and D-dimer(D-D)combined detection for short-term adverse cardiovascular events(MACE)in patients with acute heart failure.Methods:60 patients with acute heart failure from January 2022 to October 2022 were selected.After 6 months of follow-up,the patients were divided into non-MACE group(30 cases)and MACE group(30 cases)according to the occurrence of cardiac death and/or re-hospitalization due to heart failure.Serum BNP,PCT and D-D levels were detected,and the basic data.Multivariate logistic regression analysis was used,and receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy.Results:The serum levels of BNP,PCT and D-D in MACE group were higher than those in non-MACE group(P<0.05).There were significant differences in age,LVEF,LVEDd and E/A between MACE group and non-MACE group(P<0.05).logistic regression analysis showed that serum BNP,PCT and D-D levels were independent risk factors for short-term MACE in acute heart failure(P<0.05).The AUC,sensitivity,specificity and accuracy of combined detection were 95.6,90.00%、93.33%、and 91.67%,respectively,which were higher than that of single BNP,PCT and D-D.Conclusions:The combined detection and real-time monitoring of BNP,PCT and D-D can be used as a predictor of short-term adverse cardiovascular events in patients with acute heart failure,which is of great significance for the prevention of short-term adverse cardiovascular events.

关 键 词：心力衰竭 B型脑利钠肽 降钙素 D-二聚体 受试者工作特征曲线 

分 类 号：R541.6[医药卫生—心血管疾病]