复合人参葵花盘抗痛风与高尿酸血症的作用研究  

Effect of Composite Ginseng and Sunflower Plate on Ameliorating Gout and Hyperuricemia

作　　者：李志满 李田野 王玉 孙印石[1] LI Zhiman;LI Tianye;WANG Yu;SUN Yinshi(Institute of Special Animals and Plants of Chinese Academy of Agricultural Sciences,Changchun 130112,China;Jilin Institute of Deer and Ginseng and Ganoderma Industrial Research,Changchun 130061,China;Jilin Yuanbo Pharmaceutical Technology Company Limited,Changchun 130022,China)

机构地区：[1]中国农业科学院特产研究所,吉林长春130112 [2]吉林省鹿参芝产业研究院,吉林长春130061 [3]吉林省远播医药科技有限公司,吉林长春130022

出　　处：《特产研究》2023年第6期98-102,共5页Special Wild Economic Animal and Plant Research

基　　金：中央级公益性科研院所基本科研业务费专项项目(CAAS-ASTIP-ISAPS-2021-010)。

摘　　要：探讨复合人参葵花盘对大鼠急性痛风性关节炎和小鼠高尿酸血症的作用。复合人参葵花盘每天通过灌胃方式给予大鼠1次,共7 d。在第6天时,将尿酸钠注射到大鼠右侧踝关节中,建立大鼠急性痛风性关节炎模型。测量大鼠踝关节的周长,计算大鼠踝关节的肿胀程度。收集血清,利用ELISA方法检测炎症因子TNF-α和IL-6的含量。在小鼠高尿酸血症模型中,灌胃酵母膏和复合人参葵花盘,共8d,第5~8天,腹腔注射氧嗪酸钾盐,每天1次。检测肾功能指标与黄嘌呤氧化酶(XOD)活力。结果与模型组相比,复合人参葵花盘在1、2、4、6、8、24 h显著减轻痛风性关节炎大鼠踝关节肿胀程度,改善了痛风大鼠的行走障碍,减少了血清中TNF-α和IL-6的含量。复合人参葵花盘可以降低高尿酸血症小鼠血清中尿酸、肌酐和尿素氮的水平,能够抑制XOD活性从而减少尿酸生成。复合人参葵花盘有较好的抗炎作用以及抑制XOD活性的能力,具有治疗急性痛风性关节炎和改善高尿酸血症作用。Effect of Composite Ginseng and sunflower plate(CGS)on acute gouty arthritis in rats and hyperuricemia in mice was studied.We established acute gouty arthritis in rats were continuously gavaged CGS once a day for 7 days.On the 6th day,sodium urate was injected into the ankle joint of rats,and measured the degree of ankle swelling.The contents of TNF-α and IL-6 inflammatory factors in serum were detected by ELISA.In a mouse model of hyperuricemia,mice were gavaged yeast extract and CGS for 8 days,from the 5th day to the 8th day,the mice were also intraperitoneally injected with potassium oxazonate,once a day.Renal function indexes and xanthine oxidase(XOD)activity were measured.The results showed that CGS signifcantly reduced ankle swelling at 1,2,4,6,8,and 24 h,improved walking disorder gait,and reduced serum levels of inflammatory cytokines TNF-α and IL-6 in gouty arthritis rats in comparison with model group.CGS can also reduce the level of uric acid,creatinine and urea nitrogen in the serum of hyperuricemic mice,inhibit the activity of XOD,thereby re-ducing the production of uric acid.It is conduded that composite sunflower plate has a good anti-inflammatory effect and the ability to inhibit XOD activity,which can achieve the effect of treating acute gouty arthritis and improving hyperuricemia.

关 键 词：复合人参葵花盘 痛风 关节炎 高尿酸血症 

分 类 号：R285.5[医药卫生—中药学]