柔性电化学传感器及其在无创医学检测中的应用  

Flexible Electrochemical Sensors and Their Applications in Noninvasive Medical Detection

作　　者：梁华润 马浩轩 段新荣 于洁 王灏珉 李硕[1] 朱梦嘉 陈爱兵[2] 郑晖 张莹莹[1] Liang Huarun;Ma Haoxuan;Duan Xinrong;Yu Jie;Wang Haomin;Li Shuo;Zhu Mengjia;Chen Aibing;Zheng Hui;Zhang Yingying(Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084,China;School of Chemical and Pharmaceutical Engineering,Hebei University of Science&Technology,Shijiazhuang 050091,China;Department of Anesthesiology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]清华大学化学系、有机光电子与分子工程教育部重点实验室,北京100084 [2]河北科技大学化学与制药工程学院,石家庄050091 [3]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院麻醉科,北京100021

出　　处：《化学学报》2023年第10期1402-1419,共18页Acta Chimica Sinica

基　　金：国家自然科学基金(Nos.21975141,52125201);北京市科学技术委员会、中关村科技园区管理委员会(No.Z221100002722015)资助.

摘　　要：电化学传感器因其响应速度快、灵敏度高、选择性好和易于定量化而被广泛用于检测物质浓度.随着柔性电子技术的迅速发展,电化学传感器已发展为柔性可穿戴形态,被用于生物液/气流体的原位分析,从而以便携、无创的方式实现对生理指标和健康状态的连续监测,在智慧健康与医疗领域展现出巨大潜力.有鉴于此,本综述聚焦于面向无创医学检测的柔性电化学传感器的设计与应用,首先介绍了柔性电化学传感器的基本构成,然后讨论了各种类型传感器的工作原理,接着系统性综述了柔性电化学传感器在汗液、间质液、泪液、唾液和呼吸等典型生物流体中重要化学物质检测方面的最新进展.最后,总结并讨论了柔性电化学传感器所面临的挑战与机遇,展望了其在无创健康监测和精准医疗方面的前景.Electrochemical sensors are widely employed for the detection of substance concentrations owing to their rapid response,high sensitivity,remarkable selectivity,and ease of quantification.With the rapid advancements in flexible electronics technology,electrochemical sensors have been transitioned into flexible and wearable formats,facilitating the in-situ analysis of biological liquids or gases.This breakthrough has opened avenues for portable,noninvasive continuous monitoring of physiological parameters and health status,thereby unveiling vast potential in the realm of intelligent healthcare and medical applications.Building upon these remarkable progressions,this paper primarily focuses on the design and applications of flexible electrochemical sensors tailored specifically for noninvasive medical detection.Firstly,the basic components of flexible electrochemical sensors are elucidated.Subsequently,the working principles of various types of sensors are expounded upon.Furthermore,we systematically review the latest advancements in the detection of pivotal chemical substances in typical biofluids such as sweat,interstitial fluid,tears,saliva,and breath,using flexible electrochemical sensors.Finally,the challenges and opportunities of flexible electrochemical sensors for applications in noninvasive health monitoring and precision medicine are discussed and proposed.

关 键 词：电化学传感 柔性可穿戴器件 生物流体 无创检测 健康管理 

分 类 号：O657.1[理学—分析化学] R313[理学—化学]