普瑞巴林联合脉冲射频治疗带状疱疹后神经痛的临床效果  

Clinical Effect of Pregabalin Combined with Pulsed Radiofrequency in the Treatment of Postherpetic Neuralgia

作　　者：李伟兴 林冠林 陈振明 蔡振宇[1] LI Weixing;LIN Guanlin;CHEN Zhenming;CAI Zhenyu(The First Affiliated Hospital of Xiamen University,Xiamen 361003,China)

机构地区：[1]厦门大学附属第一医院,福建厦门361003

出　　处：《中外医学研究》2023年第31期38-41,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究普瑞巴林联合脉冲射频(PRF)治疗带状疱疹后神经痛(PHN)的临床效果。方法:选取2021年3月—2022年9月厦门大学附属第一医院疼痛科收治的70例PHN患者,依据治疗方案差异分为的PRF组(采用普瑞巴林联合PRF治疗)与NB组[采用普瑞巴林联合神经阻滞(NB)],各35例。比较两组治疗前后疼痛程度、临床效果、睡眠质量及不良反应发生情况。结果:治疗前,两组视觉模拟评分法(VAS)评分比较,差异无统计学意义(P>0.05);治疗后1周、4周及12周,两组VAS评分显著低于治疗前,且PRF组低于NB组,治疗后4周及12周,两组VAS评分显著低于治疗后1周,治疗后12周,两组VAS评分显著低于治疗后4周,差异有统计学意义(P<0.05)。PRF组总有效率为94.29%,显著高于NB组的74.29%,差异有统计学意义(P<0.05)。治疗前,两组匹兹堡睡眠质量指数(PSQI)评分比较,差异无统计学意义(P>0.05);治疗后1周、4周及12周,两组PSQI评分显著低于治疗前,且PRF组低于NB组,治疗后4周及12周,两组PSQI评分显著低于治疗后1周,治疗后12周,两组PSQI评分显著低于治疗后4周,差异有统计学意义(P<0.05)。PRF组不良反应发生率为17.14%,显著低于NB组的40.00%,差异有统计学意义(P<0.05)。结论:普瑞巴林联合PRF治疗PHN具有确切的效果,可显著减轻患者疼痛,改善患者睡眠质量,同时不良反应发生较少。Objective:To explore the clinical effect of Pregabalin combined with pulsed radiofrequency(PRF)on postherpetic neuralgia(PHN).Method:A total of 70 PHN patients admitted to the Pain Department of the First Affiliated Hospital of Xiamen University from March 2021 to September 2022 were selected and divided into PRF group(treated with Pregabalin combined with PRF)and NB group[treated with Pregabalin combined with nerve block(NB)]according to the difference in treatment plans,with 35 cases in each group.The pain degree,clinical efficacy,sleep quality before and after treatment and adverse reactions were compared between the two groups.Result:Before treatment,there was no significant difference in visual analogue scale(VAS)scores between the two groups(P>0.05).At 1 week,4 weeks and 12 weeks after treatment,VAS scores in two groups were significantly lower than those before treatment,and PRF group were lower than those in the NB group,at 4 weeks and 12 weeks after treatment,the VAS score of the two groups were significantly lower than that of 1 week after treatment,and at 12 weeks after treatment,the VAS scores of the two groups were significantly lower than that of 4 weeks after treatment,the differences were statistically significant(P<0.05).The total effective rate of PRF group was 94.29%,which was significantly higher than 74.29%of NB group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in Pittsburgh sleep quality index(PSQI)scores between the two groups(P>0.05).At 1 week,4 weeks and 12 weeks after treatment,PSQI scores in two groups were significantly lower than those before treatment,and PRF group were lower than those in NB group,at 4 weeks and 12 weeks after treatment,the PSQI scores of the two groups were significantly lower than that of 1 week after treatment,and at 12 weeks after treatment,the PSQI scores of the two groups were significantly lower than that of 4 weeks after treatment,the differences were statistically significant(P<0.05).The complica

关 键 词：带状疱疹后神经痛 普瑞巴林 脉冲射频 神经阻滞 视觉模拟评分法 匹兹堡睡眠质量指数 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]