小剂量丙种球蛋白辅助治疗对重症ITP患儿Th17/Treg平衡及血小板功能的影响  

Effect of Low-dose Gamma Globulin Adjuvant Therapy on Th17/Treg Balance and Platelet Function in Children with Severe ITP

作　　者：李丽雯 张丽萍 邱雪文 LI Liwen;ZHANG Liping;QIU Xuewen(Longyan First Hospital,Longyan 364000,China)

机构地区：[1]龙岩市第一医院,福建龙岩364000

出　　处：《中外医学研究》2023年第31期115-118,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究小剂量丙种球蛋白辅助治疗对重症原发免疫性血小板减少症(ITP)患儿辅助性T细胞17(Th17)/调节性T细胞(Treg)平衡及血小板功能的影响。方法:选取2020年5月—2021年3月在龙岩市第一医院进行治疗的80例重症ITP患儿作为研究对象,采用随机数表法分为观察组和对照组,各40例。对照组采用常规激素治疗,观察组采用常规激素联合小剂量丙种球蛋白治疗。观察比较两组治疗前后Th17/Treg平衡、血小板压积(PCT)、血小板体积分布宽度(PDW)、血小板计数(PLT)水平,记录治疗不良反应发生率。结果:治疗前,两组Th17、Treg及Th17/Treg比较,差异无统计学意义(P>0.05);治疗4周后,两组Th17、Th17/Treg均低于治疗前,Treg高于治疗前,且观察组Th17、Th17/Treg低于对照组,Treg高于对照组,差异有统计学意义(P<0.05)。治疗前,两组PCT、PDW、PLT水平比较,差异无统计学意义(P>0.05);治疗4周后,两组PCT、PLT水平均高于治疗前,PDW水平均低于治疗前,且观察组PCT、PLT水平高于对照组,PDW水平低于对照组,差异有统计学意义(P<0.05)。治疗过程中,两组均未出现出血、头痛、发热、感染等不良反应。结论:采用常规治疗联合小剂量丙种球蛋白治疗对重症ITP患儿Th17/Treg平衡及改善血小板功能具有一定作用。Objective:To investigate the effect of low-dose Gamma Globulin adjuvant therapy on the balance of helper T cell 17(Th17)/regulatory T cell(Treg)and platelet function in children with severe primary immune thrombocytopenia(ITP).Method:A total of 80 children with severe ITP treated in Longyan First Hospital from May 2020 to March 2021 were selected as the study objects and divided into observation group and control group by random number table method,with 40 cases in each group.The control group was treated with conventional hormone therapy,and the observation group was treated with conventional hormone combined with low-dose Gamma Globulin.Th17/Treg balance,platelet accumulation(PCT),platelet volume distribution width(PDW)and platelet count(PLT)levels before and after treatment were observed and compared between the two groups,and the incidence of adverse reactions was recorded.Result:Before treatment,there were no significant differences in Th17,Treg and Th17/Treg between the two groups(P>0.05).After 4 weeks of treatment,Th17 and Th17/Treg in both groups were lower than those before treatment,and Treg were higher than those before treatment,and Th17 and Th17/Treg in observation group were lower than those in the control group,and Treg was higher than that in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in PCT,PDW and PLT levels between the two groups(P>0.05).After 4 weeks of treatment,PCT and PLT levels in both groups were higher than those before treatment,and PDW levels were lower than those before treatment,and PCT and PLT levels in observation group were higher than those in the control group,and PDW levels was lower than that in the control group,the differences were statistically significant(P<0.05).During the treatment,there were no adverse reactions such as bleeding,headache,fever,infection in both groups.Conclusion:The combination of conventional therapy and low-dose Gamma Globulin therapy can improve Th17/Treg balance and

关 键 词：Th17/Treg平衡 丙种球蛋白 血小板功能 重症原发免疫性血小板减少症 

分 类 号：R725.5[医药卫生—儿科]