益气温阳活血方联合温针灸在老年性骨质疏松症中的临床疗效  

Clinical Effect of Yiqi Wenyang Huoxue Prescription Combined with Warm Acupuncture and Moxibustionin in Senile Osteoporosis

作　　者：林容枝 林艳萍 林清云 LIN Rongzhi;LIN Yanping;LIN Qingyun(Fujian Geriatric Hospital,Fuzhou 350000,China)

机构地区：[1]福建省老年医院,福建福州350000

出　　处：《中外医学研究》2023年第32期120-123,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨益气温阳活血方联合温针灸对老年性骨质疏松症的临床疗效。方法:选取2022年2—12月福建省老年医院收治的52例老年性骨质疏松症患者作为研究对象,按随机数表法分为对照组和观察组,各26例。对照组采用常规西药联合温针灸治疗,观察组在对照组基础上联用益气温阳活血方治疗。比较两组临床疗效、治疗前后骨密度、骨源性碱性磷酸酶(BALP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTx)、Ⅰ型胶原交联C末端肽(S-CTx)水平及不良反应发生情况。结果:观察组总有效率为96.15%,明显高于对照组的73.08%,差异有统计学意义(P<0.05)。治疗前,两组胸椎、股骨颈骨密度比较,差异无统计学意义(P>0.05),治疗后,两组胸椎、股骨颈骨密度均高于治疗前,且观察组胸椎、股骨颈骨密度显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组骨代谢指标比较,差异无统计学意义(P>0.05);治疗后,两组血清β-CTx、S-CTx水平低于治疗前,血清BALP高于治疗前,且观察组血清β-CTx、S-CTx水平均低于对照组,血清BALP高于对照组,差异有统计学意义(P<0.05)。两组均未见嗳气、便秘、高血钙、肾功能不全、肌肉酸痛、骨痛、软弱无力、软组织钙化等不良反应发生。结论:益气温阳活血方联合温针灸治疗老年性骨质疏松症可以有效减轻临床症状,效果显著,可改善骨代谢,维持患者骨量,且安全性高。Objective:To explore the clinical effect of Yiqi Wenyang Huoxue Prescription combined with warm acupuncture and moxibustion on senile osteoporosis.Method:A total of 52 patients with senile osteoporosis admitted to Fujian Geriatric Hospital from February to December 2022 were selected as the study objects,and they were divided into control group and observation group according to random number table method,with 26 cases in each group.The control group was treated with conventional western medicine combined warm acupuncture and moxibustion,and observation group was treated with Yiqi Wenyang Huoxue Prescription based on control group.The clinical efficacy,bone mineral density,bone-derived alkaline phosphatase(BALP),typeⅠcollagen carboxy terminal peptideβspecial sequence(β-CTx),typeⅠcollagen cross-linked C-terminal peptide(S-CTx)before and after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was 96.15%,which was significantly higher than 73.08%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in bone mineral density of thoracic vertebrae and femoral neck between the two groups(P>0.05).After treatment,bone mineral density of thoracic vertebrae and femoral neck between the two groups were higher than those before treatment,and bone mineral density of thoracic vertebrae and femoral neck in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in bone metabolism indexes between the two groups(P>0.05).After treatment,serumβ-CTx and S-CTx levels in two groups were lower than those before treatment,serum BALP were higher than those before treatment,and serumβ-CTx and S-CTx levels in observation group were lower than those in control group,serum BALP was higher than that in control group,the differences were statistically si

关 键 词：益气温阳活血方 温针灸 老年性骨质疏松症 临床疗效 股骨颈骨密度 骨源性碱性磷酸酶 Ⅰ型胶原羧基端肽β特殊序列 

分 类 号：R259[医药卫生—中西医结合]