Formulated nano-liposomes for reversal of cisplatin resistance in NSCLC with nucleus-targeting peptide  

作　　者：Minxian Li Mei Jiang Mengting Chen Lilusi Ma Xiaocui Fang Yanlian Yang Chen Wang 

机构地区：[1]Key Laboratory for Biological Effects of Nanomaterials and Nanosafety(Chinese Academy of Sciences),Key Laboratory of Standardization and Measurement for Nanotechnology(Chinese Academy of Sciences),and CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing 100190,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Sino-Danish Center for Education and Research,Sino-Danish College,Beijing 101499,China [4]Central Laboratory,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China

出　　处：《Nano Research》2023年第11期12864-12879,共16页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.32101130,21721002,and 31971295);Financial support from Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)is also gratefully acknowledged.

摘　　要：Cell membrane-engineered nano-delivery systems have evolved as a promising strategy to enhance drug bioavailability,offering an alternative for reversing drug resistance in cancer therapy.Herein,a formulated nano-liposome that fabricated by hybridizing cisplatin-resistant A549 cell line(A549/cis)cancer cell membrane and phospholipids for co-delivery of cisplatin and nuclear protein zeste homolog 2(EZH2)-targeting peptide EIP103,referred to as cLCE,was developed.In vitro results indicated that the formulated nano-liposome can efficiently inhibit A549/cis cancer cell invasion and metastasis through the down-regulation of Ncadherin and vimentin proteins.Mechanistic studies demonstrated that the reduction of nerve growth factor receptor(NGFR)levels and the increase of peroxisome proliferator-activated receptorγ(PPARγ)levels achieved by EIP103 may contribute to the reversal of cisplatin resistance.In vivo results demonstrated that the encapsulation of both cisplatin and EIP103 within cLCE leads to increased intratumoral accumulation and prolonged survival in A549/cis cancer-bearing mice as compared to the individual drugs alone.This can be attributed to the enhanced tumor homing capability of cLCE achieved through the presence of inherited membrane proteins derived from A549/cis cells.Taken together,this study may provide a highly promising therapeutic strategy to improve clinical treatments for cisplatin-resistance non-small-cell lung cancer(NSCLC)as well as other malignant cancers.

关 键 词：formulated liposome tumor homing cisplatin resistance nucleus-peptide cancer therapy 

分 类 号：TB383[一般工业技术—材料科学与工程]