病毒性心肌炎患者血清IL-37、cTnl、Bcl-2水平变化及其与预后的关系研究  

Serum levels of IL-37, cTnl and Bcl-2 among patients with viral myocarditis and their relationship with prognosis

作　　者：赵丽杰 卢冬梅[2] 部纪春 李宝华[4] Zhao Lijie;Lu Dongmei;Bu Jichun;Li Baohua(Department of Clinical Laboratory,Chengde Rongfu Military Hospital,Chengde 067200,China;Department of Clinical Laboratory,Affiliated Hospital of Chengde Medical College,Chengde 067200,China;Department of Clinical Laboratory,Chengde Stomatological Hospital,Chengde 067200,China;Department of Clinical Laboratory,Chengde Central Hospital,Chengde 067200,China)

机构地区：[1]承德市荣复军人医院检验科,067200 [2]承德医学院附属医院检验科,067200 [3]承德市口腔医院检验科,067200 [4]承德市中心医院检验科,067200

出　　处：《国际病毒学杂志》2023年第5期380-383,共4页International Journal of Virology

摘　　要：目的探究病毒性心肌炎(viral myocarditis,VMC)患者血清白介素-37(interleukin-37,IL-37)、心肌肌钙蛋白I(cardiac troponin I,cTnI)及B淋巴细胞瘤-2基因(B-cell lymphoma-2,BCL-2)水平及其与预后的关系。方法选择本院2018年6月至2021年6月收治的VMC患者200例为研究组,同期体检健康人员100例为对照组,测定并对比2组血清IL-37、cTnI和Bcl-2水平,通过受试者工作特征曲线分析血清IL-37等指标对VMC的诊断效能;另通过logistic回归分析血清指标与预后的关系。结果研究组血清IL-37及cTnI水平均高于对照组(t=17.187、19.452,P均小于0.01),Bcl-2水平显著低于对照组(t=17.145,P<0.001);治疗后VMC患者血清IL-37、cTnI水平对比治疗前均显著下降(t=30.521、42.426,均P<0.01),Bcl-2水平显著上升(t=25.227,P<0.01)。血清IL-37、cTnI、Bcl-2诊断VMC的曲线下面积分别为0.945、0.961、0.911,3项联合诊断曲线下面积为0.998,敏感度、特异度对应98.50%、97.00%。Logistic回归分析显示IL-37、cTnI、Bcl-2水平与VMC患者不良预后有关(OR=1.041,P<0.01;OR=90.740,P=0.01;OR=0.007,P<0.01)。结论VMC患者血清IL-37、cTnI水平上升,Bcl-2下降,三者对VMC诊断及预后评估有较大的价值。Objective To investigate the levels of serum interleukin-37(IL-37),cardiac troponin I(cTnI),B lymphoblastoma-2 gene(Bcl-2)in patients with viral myocarditis(VMC)and their relationship with prognosis.Methods A total of 200 VMC patients admitted to our hospital from June 2018 to June 2021 were selected as the study group,and 100 healthy people who underwent physical examination during the same period were selected as the control group.The serum levels of IL-37,cTnI and Bcl-2 in the two groups were measured and compared.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic efficacy of serum IL-37 and other indicators for VMC.The relationship between serum indicators and prognosis was analyzed by logistic regression.Results The levels of serum IL-37 and cTnI in the study group were significantly higher than those in the control group(t=17.187 and 19.452,P<0.01),and the level of Bcl-2 was significantly lower than that in the control group(t=17.145,P<0.001).After treatment,the levels of serum IL-37 and cTnI in VMC patients significantly decreased compared with the results before treatment(t=30.521,42.426,P<0.01),while the level of Bcl-2 significantly increased(t=25.227,P<0.01).The area under curve(AUC)of serum IL-37,cTnI and Bcl-2 in the diagnosis of VMC was 0.945,0.961 and 0.911,respectively.The AUC for combined diagnosis was 0.998 and the sensitivity and specificity were 98.50%and 97.00%,respectively.Logistic regression analysis showed that the levels of IL-37,cTnI and Bcl-2 were respectively associated with poor prognosis of VMC patients(OR=1.041,P<0.01;OR=90.740,P=0.01,OR=0.007,P<0.01).Conclusions The serum levels of IL-37 and cTnI increased while Bcl-2 decreased in patients with VMC.The three criteria were of significant values in the diagnosis and prognosis evaluation of VMC.

关 键 词：病毒性心肌炎 白介素-37 心肌肌钙蛋白I B淋巴细胞瘤-2基因 预后 

分 类 号：R542.21[医药卫生—心血管疾病]