烟台市乙型病毒性肝炎相关性疾病的疾病负担调查研究  

Investigation on disease burden of hepatitis B related diseases in Yantai city

作　　者：李娜[1] 李波[1] 崔伟红 孙源[1] 张馨心 陈鹏[1] Li Na;Li Bo;Cui Weihong;Sum Yuan;Zhang Xinxin;Chen Peng(Department of Immunization and Prevention,Yantai Municipal Center for Disease Control and Prevention 264003,China;Shandong College of Traditional Chinese Medicine,Yantai 264004,China)

机构地区：[1]山东省烟台市疾病预防控制中心免疫预防科,264003 [2]山东中医药高等专科学校,烟台264004

出　　处：《国际病毒学杂志》2023年第5期400-403,共4页International Journal of Virology

基　　金：山东省医药卫生科技发展计划(2019WS262);中国肝炎防治基金会中国乙肝防控科研基金(YGFK20180070)。

摘　　要：目的描述烟台市2018—2019年的乙型肝炎(乙肝)及相关性肝癌的流行病学特征,了解乙肝及相关肝癌的经济负担。方法通过中国疾病预防控制信息系统分析烟台市乙肝及相关性肝癌的发病率和病死率指标,进行流行病学特征分析。计算因早死所致的寿命损失年(years of life lost,YLL)并评价流行病学负担,测算乙肝及其相关肝癌的经济负担。结果烟台市2018—2019年共报告乙肝发病率12.55/10万。乙肝相关疾病引起的年均YLL为1313人年。乙肝相关疾病平均总费用16535.0元,由高到低分别是肝癌、肝硬化失代偿期、急性乙肝、慢性乙肝和肝硬化,平均总费用分别是24201.4元、21846.0元、18040.3元、15082.5元和12808.2元;而年人均经济负担由高到低分别是肝癌、肝硬化失代偿期、肝硬化代偿期、慢性乙肝和急性乙肝,分别是37925.04元、28506元、19454.7元、20635.15元和20740.3元。其中,直接医疗费用占比最高,平均13288.9元,占80.37%;间接费用平均为2818.6元,占17.05%;直接非医疗费用平均427.5元,占2.59%。结论2018—2019年烟台市乙肝肝癌的疾病负担最重,乙肝肝硬化次之,乙型肝炎较轻。Objective To describe the epidemiological characteristics of hepatitis B and related liver cancer in Yantai from 2018 to 2019,so as to understand the economic burden of hepatitis B and related liver cancer.Methods The prevalence and mortality of hepatitis B and liver cancer in Yantai were analyzed by China Disease Control and Prevention Information System to summarize the epidemiological characteristics.The years of life lost(YLL)was calculated and the epidemiological burden was assessed.The economic burden of hepatitis B and related liver cancer were then estimated.Results The reported incidence of hepatitis B in Yantai from 2018 to 2019 was 12.55/100000 The annual YLL caused by hepatitis B related diseases was 1313 person-years.The average total cost of hepatitis B related diseases was 16535.0 yuan,and the costs from high to low were 24201.4 yuan,21846.0 yuan,18040.3 yuan,15082.5 yuan and 12808.2 yuan for liver cancer,decompensated stage of cirrhosis,acute hepatitis B,chronic hepatitis B and hepatitis B cirrhosis,respectively.The annual per capita economic burden of liver cancer,decompensated liver cirrhosis,compensatory liver cirrhosis,chronic hepatitis B and acute hepatitis B were 37925.04 yuan,28506 yuan,19454.7 yuan,20635.15 yuan and 20740.3 yuan,respectively.Among the costs,the proportion of direct medical expenses with an average of 13288.9 yuan was the highest,accounting for 80.37%.The average indirect cost was 2818.6 yuan,accounting for 17.05%.The average direct non-medical expenses was 427.5 yuan,accounting for 2.59%.Conclusions The burden of hepatitis B-related liver cancer in Yantai from 2018 to 2019 was the highest,followed by cirrhosis,and burden by hepatitis B was the relatively low.

关 键 词：乙型病毒性肝炎 肝癌 肝硬化 伤残调整寿命年 疾病负担 

分 类 号：R512.62[医药卫生—内科学]