甲状腺刺激性免疫球蛋白的测定及现状  

Determination and Present Situation of Thyroid Stimulating Immunoglobulin

作　　者：林铭旭 蔡佩珊 陈玉华 宁洁[1,3] LIN Ming-xu;CAI Pei-shan;CHEN Yu-hua;NING Jie(The First Clinical College of Medicine,Guangdong Medical University,Zhanjiang 524001,Guangdong,China;Department of Endocrinology,Shenzhen Longgang District People’s Hospital,Shenzhen 518172,Guangdong,China;Department of Endocrinology,Shenzhen Longhua District Central Hospital,Shenzhen 518110,Guangdong,China)

机构地区：[1]广东医科大学第一临床医学院,广东湛江524001 [2]深圳市龙岗区人民医院内分泌代谢科,广东深圳518172 [3]深圳市龙华区中心医院代谢内分泌科,广东深圳518110

出　　处：《医学信息》2023年第24期188-192,共5页Journal of Medical Information

摘　　要：甲状腺刺激性免疫球蛋白(TSI),又称甲状腺刺激性抗体(TSAb),是促甲状腺激素受体抗体(TRAb)中的一种,其在自身免疫性疾病,尤其是甲状腺疾病中的作用尤为重要。TSI的测定不仅对Graves病(GD)、Grave眼病(GO)的诊断、治疗以及预后评估有着重要的临床意义,对新生儿甲状腺功能亢进、妊娠期甲状腺功能亢进以及其他的甲状腺异常的风险评估也有重要价值。本文重点阐述TSI的测定原理以及在GD等甲状腺相关疾病中诊断、鉴别诊断、治疗、预后风险评估等重要作用的研究进展,以期为TSI在临床上的应用提供指导。Thyroid stimulating immunoglobulin(TSI),also known as thyroid stimulating antibody(TSAb),is one of the thyroid stimulating hormone receptor antibodies(TRAb).It plays an important role in autoimmune diseases,especially in thyroid diseases.The determination of TSI has important clinical significance not only for the diagnosis,treatment and prognosis evaluation of Graves disease(GD)and Grave ophthalmopathy(GO),but also for the risk assessment of neonatal hyperthyroidism,pregnancy hyperthyroidism and other thyroid abnormalities.This article focuses on the determination principle of TSI and the research progress of its important role in diagnosis,differential diagnosis,treatment and prognostic risk assessment of thyroid related diseases such as GD,in order to provide guidance for the clinical application of TSI.

关 键 词：甲状腺刺激性免疫球蛋白 甲状腺刺激性抗体 GRAVES病 

分 类 号：R581[医药卫生—内分泌]