A multifunctional osteogenic system of ultrasonically spray deposited bone-active coatings on plasma-activated magnesium  

作　　者：Hui Fang Shicheng Zhou Xiaoyun Qi Chenxi Wang Yanhong Tian 

机构地区：[1]State Key Laboratory of Advanced Welding and Joining,Harbin Institute of Technology,Harbin 150001,China

出　　处：《Journal of Magnesium and Alloys》2023年第8期2719-2739,共21页镁合金学报（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant No.51975151);the Heilongjiang Provincial Natural Science Foundation of China(Grant No.LH2019E041);the Heilongjiang Touyan Team.

摘　　要：Biomimetic bone-active coatings composed of inorganic nano-hydroxyapatite(i.e.,nHA)and organic silk fibroin(i.e.,SF)are layer-by-layer deposited on Mg-Zn-Ca alloy by a controllable ultrasonic spray method.Meanwhile,plasma activation is developed as a promising strategy to pretreat magnesium surfaces,which facilitates the direct adhesion of coatings with enhanced bonding interfaces.In this work,we engineer the nHA/SF composite coatings with excellent mechanical properties and adhesion force.The optimized parameters of ultrasonic spray bring significant influence on the surface morphologies of coatings.Assisted by hybrid plasma of oxygen and nitrogen(i.e.,O_(2)/N_(2) plasma),the activated Mg-Zn-Ca surfaces are uniformly covered by a robust and compact nHA/SF composite coating,establishing a multifunctional system with superior corrosion resistance and biological performance.Interestingly,secondary oxygen plasma treatment of nHA/SF coatings(A-nHA/SF)promotes the hydrophilicity,leading to a rapid self-repair effect from surface damage.The improvement of anti-corrosion and self-repair provides a dependable platform for better cell adhesion,proliferation,spreading and differentiation.These favorable factors contribute to the preferable in vivo biocompatibility and the promotion of newly formed bones for the A-nHA/SF-coated Mg implants.This study lays important foundations for coating strategy on biomedical magnesium alloy as multifunctional osteogenic system in bioactive implantable applications.

关 键 词：Magnesium alloy HYDROXYAPATITE Silk fibroin BIOCOMPATIBILITY SELF-REPAIR 

分 类 号：R318.08[医药卫生—生物医学工程] TG174.4[医药卫生—基础医学]