Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium  

作　　者：JianLiang Zhao HanRui Cui ZeYu Gao YanZe Bi ZhenZhen Dong Yan Li CaiQi Wang 

机构地区：[1]School of ChemicalScience,University of Chinese Academy of Sciences,Beijing,100049,China [2]School of Materials Science and Engineering,Beihang University,Beijing 100083,China [3]Beijing Advanced Innovation Centre for Biomedical Engineering,Beihang University,Beijing 100191,China

出　　处：《Journal of Magnesium and Alloys》2023年第8期2789-2800,共12页镁合金学报（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(no.51671179,51971014);the Excellent teacher ability improvement project(E1E40308).

摘　　要：Biomedical magnesium is an ideal material for hard tissue repair and replacement.However,its rapid degradation and infection after implantation significantly hindersclinical applications.To overcome these two critical drawbacks,we describe an integrated strategybased on the changes in pH and Mg^(2+)triggered by magnesiumdegradation.This system can simultaneously offer anticorrosion and antibacterial activity.First,nanoengineered peptide-grafted hyperbranched polymers(NPGHPs)with excellent antibacterial activity were introduced to sodium alginate(SA)to construct a sensitive NPGHPs/SA hydrogel.The swelling degree,responsiveness,and antibacterial activity were then investigated,indicating that the system can perform dual stimulation of pH and Mg^(2+)with controllable antimicrobial properties.Furthermore,an intelligent platform was constructed by coating hydrogels on magnesium with polydopamine as the transition layer.The alkaline environment generated by the corrosion of magnesium reduces the swelling degree of the coatingso that the liquid is unfavorable for contacting the substrate,thus exhibiting superior corrosion resistance.Antibacterial testing shows that the material can effectively fight against bacteria,while hemolytic and cytotoxicity testing suggest that it is highly biocompatible.Thus,this work realizes the smart integration of anticorrosion and antibacterial properties of biomedical magnesium,thereby providing broader prospects for the use of magnesium.

关 键 词：Biomedical magnesium ANTICORROSION ANTIBACTERIAL Intelligent Nanoengineered peptide-grafted hyperbranched polymers 

分 类 号：TG146.22[一般工业技术—材料科学与工程] TG178[金属学及工艺—金属材料]