使用解谱软件识别减肥药中的成分  

Identify the Ingredients in Weight-loss Drugs Using Spectrum Analysis Software

作　　者：卢思捷 Lu Si-jie

机构地区：[1]广州禾信仪器股份有限公司,广东广州510530

出　　处：《化工设计通讯》2023年第11期102-104,共3页Chemical Engineering Design Communications

摘　　要：通过有机溶剂萃取减肥药中的部分成分,经净化后在气相色谱与质谱联用仪(GCMS)上分析检测,得到成分的谱图。经过仪器工作站分析定性出共24种有机物成分。随后使用禾信仪器的专业解谱软件对谱图再一次分析定性,通过分析得出36种有机物成分。相较GCMS工作站,禾信仪器解谱软件可多识别出50%的物质,其中最主要是在一个物质峰中识别出西布曲明和咖啡因两个物质,西布曲明为禁用药物[1],咖啡因则需要控制用量。经过数据分析得知,两种定性方法结果的差异部分大多从共流出峰和信号较弱的色谱峰中的精准分析中得来。Some components in weight-loss drugs were extracted by organic solvent,purified and analyzed by gas chromatography and mass spectrometry(GCMS)to obtain the spectrum of the components.A total of 24 organic compounds were analyzed and identified by the instrument workstation.After that,the professional spectrum analysis software of Hexin Instrument was used to analyze the spectrum again,and 36 organic compounds were obtained through analysis.Compared with GCMS workstation,Hexin instrument spectrum analysis software can identify 50%more substances,the most important of which is to identify sibutramine and caffeine in a substance peak.sibutramine is a prohibited drug,and caffeine needs to be controlled.According to the data analysis,the difference between the results of the two qualitative methods is mostly derived from the accurate analysis of the co-outflow peak and the chromatographic peak with weak signal.

关 键 词：解谱软件 GCMS 减肥药 定性分析 

分 类 号：R927.6[医药卫生—药学]