抗菌钛合金Ti24Nb4Zr8Sn-8Cu抗菌性能及生物相容性初步评价  

Preliminary Evaluation of Antibacterial Properties and Biocompatibility of Antibacterial Titanium Alloy Ti24Nb4Zr8Sn-8Cu

作　　者：李研[1] 徐翠香[1] 黄晓燕[1] 封青[1] 赵向绒[1] 靳占奎[2] LI Yan;XU Cui-xiang;HUANG Xiao-yan;FENG Qing;ZHAO Xiang-rong;JIN Zhan-kui(Shaanxi Provincial Key Laboratory of Infectious and Immune Diseases,Shaanxi People's Hospital,Xi'an 710068,China;Department of Orthopaedics,Shaanxi People's Hospital,Xi'an 710068,China)

机构地区：[1]陕西省人民医院陕西省感染与免疫疾病重点实验室,陕西西安710068 [2]陕西省人民医院骨科,陕西西安710068

出　　处：《药物生物技术》2023年第5期455-458,共4页Pharmaceutical Biotechnology

基　　金：陕西省教育厅重点项目重点实验室项目类(21JS039);陕西省人民医院人才支持计划(2021BJ-04);陕西省人民医院孵化基金(2020YXM-02)。

摘　　要：研究含铜抗菌钛合金Ti2448(Ti24Nb4Zr8Sn)的生物相容性。电弧炉熔炼的Ti24Nb4Zr8Sn和Ti24Nb4Zr8Sn-8Cu合金材料,分别与金黄色葡萄球菌、MC3T3-E1细胞共培养,通过荧光染色、显微观察、电镜观察、流式检测,来研究合金材料抗菌性能和生物相容性。Ti24Nb4Zr8Sn合金材料对金黄色葡萄球菌无抗菌作用,而Ti24Nb4Zr8Sn-8Cu合金材料对细菌有较强的抑制作用;Ti24Nb4Zr8Sn和Ti24Nb4Zr8Sn-8Cu合金材料均对MC3T3-E1细胞没有影响。Ti24Nb4Zr8Sn-8Cu合金材料拥有良好的抗菌性,具有良好的生物相容性,适合用于骨科内植入材料。To study the biocompatibility of antibacterial titanium alloy Ti2448(Ti24Nb4Zr8Sn)containing copper,Ti24Nb4Zr8Sn and Ti24Nb4Zr8Sn-8Cu alloy materials melted in electric arc furnace were co-cultured with Staphylococcus aureus and MC3T3-E1 cells respectively.The antibacterial properties and biocompatibility of the alloy materials were studied by fluorescence staining,microscopic observation,electron microscopy and flow cytometry.Ti24Nb4Zr8Sn alloy material had no antibacterial effect on Staphylococcus aureus,while Ti24Nb4Zr8Sn-8Cu alloy material had a strong inhibitory effect on bacteria;Ti24Nb4Zr8Sn and Ti24Nb4Zr8Sn-8Cu alloy materials had no effect on MC3T3-E1 cells.Ti24Nb4Zr8Sn-8Cu alloy material has good antibacterial property and biocompatibility,and is suitable for orthopedic implants.

关 键 词：Ti2448 合金材料 生物相容性 MC3T3-E1 金黄色葡萄球菌 

分 类 号：R318.08[医药卫生—生物医学工程]