Xanthone的生物合成研究进展  

Research Progess on Biosynthesis of Xanthone

作　　者：孙兰兰 王凯旋 赵玉成 秦民坚 SUN Lan-lan;WANG Kai-xuan;ZHAO Yu-cheng;QIN Min-jian(Department of Resources Science of Traditional Chinese Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学中药学院中药资源系,江苏南京211198

出　　处：《药物生物技术》2023年第5期531-537,共7页Pharmaceutical Biotechnology

摘　　要：[口山]酮(Xanthone)具有独特的C13(C6-C1-C6)碳骨架结构,是一种特殊的黄酮类化合物。[口山]酮结构多样的衍生物有广泛的生物活性和药理作用,具有显著的药用价值和经济价值。目前关于[口山]酮的研究主要集中在化学和药理活性方面,对于其生物合成机制的研究还不够全面和深入。文章梳理了近年来国内外[口山]酮的生物合成途径的相关研究,并重点介绍了参与该途径的关键酶,以期为将来通过合成生物学技术和微生物代谢工程异源生产[口山]酮及其衍生物,对[口山]酮类化合物进行深度开发利用提供有价值的参考。Xanthone has a unique C13(C6-C1-C6)carbon skeleton structure and belongs to a special kind of flavonoids.The structurally diverse derivatives of xanthones have significant and extensive biological activity and pharmacological effects,and have high medicinal value and economic value.Nowadays the research of xanthones and its derivatives mainly focuses on chemical structure and pharmacological activities,while the understanding of xanthone biosynthesis mechanism is not clear and deep enough.This paper reviewed the related researches of xanthone biosynthesis national and international in recent years,speculated the synthesis mechanism of xanthone in plant reasonably and highlighted the key enzymes involved in it,including Benzoate-CoA ligase(BZL),Benzophenone synthase(BPS),Xanthone synthase(XS),C-Glycosyltransferase(CCT)and other structural modification enzymes.This article summarized the above information with the aim of providing valuable references for the future production of xanthone and its derivatives by microbial metabolic engineering,and for the in-depth development and utilization of xanthone and its derivatives by synthetic biology approaches.

关 键 词：[口山]酮 生物合成途径 关键酶 综述 芒果苷 植物次生代谢产物 

分 类 号：R284[医药卫生—中药学]