DCE-MRI定量参数在子宫肌瘤患者皮下脂肪微循环特点研究中的应用价值  

Application Value of DCE-MRI Quantitative Parameters in the Study of Subcutaneous Fat Microcirculation in Patients with Uterine Fibroids

作　　者：秦颖 吕富荣[1] 肖智博[1] 徐勇 刘宇航[1] QIN Ying;LV Furong;XIAO Zhibo;XU Yong;LIU Yuhang(Department of Radiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院放射科,重庆400016

出　　处：《中国医疗设备》2023年第12期85-89,100,共6页China Medical Devices

基　　金：重庆市科卫联合医学科研项目(2021MSXM102)。

摘　　要：目的 探讨动态增强磁共振成像(Dynamic Contrast-Enhanced MRI,DCE-MRI)定量参数在子宫肌瘤患者下腹部皮下脂肪微循环特点研究中的应用价值。方法 收集71例接受高强度聚焦超声治疗的子宫肌瘤患者的术前DCE-MRI图像,采用盆腔轴位动态增强LAVA序列进行感兴趣区(Region of Interest,ROI)勾画,取轴位上两侧髂结节所作结节间平面为初始层面进行测量,共测量3个平面,于各层面左右两侧分别进行测量,每例患者均测量18个ROI,计算各ROI皮下脂肪定量参数:容积转运常数(Volume Transfer Constant,Ktrans)、速率常数(Rate Constant,Kep)、血管外细胞外间隙容积分数(Extravascular Extracellular Space Volume Fraction Per Unit of Tissue Volume,Ve)以及血浆容积指数(Blood Plasma Volume Per Unit Volume of Tissue,Vp)。结果 每一层各点的Ktrans、Kep、Ve值差异有统计学意义(P<0.05),且均表现为:点1>点2>点3,两点间差异有统计学意义(P<0.05);L1、L2层的Vp值差异有统计学意义(P<0.05),R1~R3及L3层Vp值差异均无统计学意义。结论 DEC-MRI可以通过定量参数量化皮下脂肪微循环的情况,不同位置皮下脂肪微循环情况有差异,各层靠近腹部中心区域的微循环较外周区域丰富。Objective To explore the value of dynamic contrast-enhanced MRI(DCE-MRI)quantitative parameters in the study of the characteristics of subcutaneous fat microcirculation in the lower abdomen of patients with uterine fibroids.Methods Preoperative DCE-MRI images of 71 patients with uterine fibroids who received high-intensity focused ultrasound treatment were collected,and the pelvic axial dynamic enhanced LAVA sequence was performed for region of interest(ROI).The internodal plane of iliac nodules on both sides of the axial position was taken as the initial plane for measurement.A total of 3 planes were measured,and each plane was measured on the left and right sides respectively.18 ROI was measured for each patient.The quantitative parameters volume transfer constant(Ktrans),rate constant(Kep),extravascular extracellular space volume fraction per unit of tissue volume(Ve)and blood plasma volume per unit volume of tissue(Vp)of subcutaneous fat in each ROI were calculated.Results The difference of Ktrans,Kep and Ve values at each point of each layer was statistically significant(P<0.05).The results were point 1>point 2>point 3,the difference between the two points was statistically significant(P<0.05).The difference of Vp values between L1 and L2 layers was statistically significant(P<0.05),but the difference of Vp values between R1-R3 and L3 layers was not statistically significant.Conclusion DEC-MRI can quantify the subcutaneous fat microcirculation through quantitative parameters.The subcutaneous fat microcirculation varies in different positions.The microcirculation of each layer near the center of the abdomen was more abundant than that of the peripheral region.

关 键 词：动态增强磁共振成像 高强度聚焦超声 皮下脂肪微循环 DCE-MRI定量参数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.33[医药卫生—诊断学]