2,3-二磷酸甘油类似物的合成及功能评价研究进展  

Advances in Synthesis and Functional Evaluation of Glycerol 2,3-diphosphate Analogues

作　　者：姚菀腾 尹紫悦 郭茜文 李文斌 王荣[1,2] YAO Wanteng;YIN Ziyue;CUO Qianwen;LI Wenbin;WANG Rong(Department of Pharmacy,The940th Hospital of PLA Joint Logistics Surpport Force,Lanzhou 730050,China;College of Pharmacy,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]中国人民解放军联勤保障部队第九四O医院药剂科,兰州730050 [2]兰州大学药学院,兰州730000

出　　处：《中国药学杂志》2023年第18期1671-1675,共5页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(82173738);部队拔尖培育项目资助(2021yxky005);全军青年培育项目资助(20QNPY070)。

摘　　要：2,3-二磷酸甘油(2,3-DPG)是血红蛋白氧亲和力的变构调节剂之一,它能与脱氧态血红蛋白(T态)结合,降低其对氧气的亲和力,增加血红蛋白在肌肉等组织中的释氧量,对维持机体缺氧有不可或缺的作用。而2,3-DPG由于透膜性较差,通过外源给药的方式起到的效果极为有限,设计可透膜的血红蛋白变构剂可为抗缺氧药物研究提供新的途径。本研究报道了2,3-DPG的作用方式、2,3-DPG类似物的研究进展及相关功能表征方法,为合成新的2,3-DPG类似物提供新的思路。Glycerol 2,3-diphosphate(2,3-DPG)is one of the allosteric regulators of oxygen affinity of hemoglobin.It can combine with deoxygenated hemoglobin(T-state),reduce its affinity for oxygen,increase the oxygen release of hemoglobin in muscles and other tissues,and play an indispensable role in maintaining hypoxia.However,the effect of exogenous administration of 2,3-DPG is extremely limited due to its poor membrane permeability.The design of membrane permeable hemoglobin allosteric agent can provide a new way for the study of anti-hypoxia drugs.This article reviews the action mode of 2,3-DPG,the research progress of 2,3-DPG analogues and related functional characterization methods to provide new ideas for synthesis of novel 2,3-DPG analogues.

关 键 词：2 3-二磷酸甘油酸 血红蛋白 变构剂 亲脂性化合物 高原缺氧 

分 类 号：G353[文化科学—情报学]