OSAHS患者血清可溶性髓样细胞触发受体2水平的变化及其意义  

The evaluation of serum soluble triggering receptor expresses on myeloid cells 2 levels in patients with OSAHS

作　　者：阚海峰[1] 马兰玉 陈龙[1] KAN Haifeng;MA Lanyu;CHEN Long(Pulmonary and Critical Care Medicine,Rugao People's Hospital,Nantong 226500,China)

机构地区：[1]如皋市人民医院呼吸与危重症医学科,江苏南通226500

出　　处：《现代医学》2023年第10期1423-1427,共5页Modern Medical Journal

摘　　要：目的:检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清可溶性髓样细胞触发受体2(sTREM2)水平并探讨其临床意义。方法:选取在我院门诊和住院接受多导睡眠(PSG)监测的人群作为受试者,根据睡眠呼吸暂停低通气指数(AHI)将受试者分为OSAHS组61例(AHI≥5次·h^(-1))和对照组30例(AHI<5次·h^(-1))。根据蒙特利尔认知评估(MoCA)将OSAHS组分成认知功能正常(MoCA得分≥26分,41例)和合并轻度认知功能障碍(MCI)(MoCA得分<26分,20例)。采用ELISA法测定所有受试者的血清sTREM2的含量。结果:OSAHS组患者的血清sTREM2水平较对照组升高(P<0.05),且与认知功能正常的OSAHS患者相比,合并MCI的OSAHS患者血清sTREM2水平更高(P<0.05)。OSAHS患者的sTREM2水平受MoCA评分、平均血氧饱和度(MSaO 2)和血氧饱和度低于90%的时间占总监测时间的百分比(TS90%)的影响,MoCA评分、MSaO 2较低且TS90%较高的OSAHS患者血清sTEM2水平可能更高。结论:OSAHS患者血清sTREM2水平升高,尤其是合并MCI的患者。因此,血清sTREM2水平有可能成为OSAHS患者MCI的生物标志物。Objective:This study aimed to compare serum levels of soluble triggering receptor expresses on myeloid cells 2(sTREM2)in normal individuals and patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods:People who received polysomnography(PSG)monitoring in our hospital were selected as subjects.According to the sleep apnea-hypopnea index(AHI),the subjects were divided into OSAHS group(AHI≥5 times·h-1,n=61)and control group(AHI<5 times·h-1,n=30).According to the Montreal cognitive assessment(MoCA)score,the patients of OSAHS group were divided into the normal cognitive function(MoCA≥26 points,n=41)and the mild cognitive impairment(MCI)(MoCA<26 points,n=20).The serum STREM2 content was determined by ELISA in all subjects.Results:OSAHS group had higher serum sTREM2 levels than the control group(P<0.05).Additionally,serum sTREM2 levels were higher in OSAHS patients with MCI(P<0.05).Multivariate linear regression analysis showed that serum sTREM2 levels in patients with OSAHS were associated with the MoCA score,MSaO 2 and TS90%levels.OSAHS Patients with low MoCA scores,low MSaO 2,and higher TS90%may have higher serum sTEM2 levels.Conclusion:Serum sTREM2 levels are elevated in patients with OSAHS,especially those with MCI.Therefore,serum sTREM2 levels have the potential to become biomarker of MCI in OSAHS patients.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 可溶性髓样细胞触发受体2 认知功能障碍 

分 类 号：R563.9[医药卫生—呼吸系统]