清营颗粒对大鼠的亚慢性毒性评价  

Evaluation of Subchronic Toxicity of Qingying Granules in Rat

作　　者：张瑜 刘月月[1,2] 杨鹏 李克鑫 殷斌 赵增成[1,2] 林树乾 ZHANG Yu;LIU Yueyue;YANG Peng;LI Kexin;YIN Bin;ZHAO Zengcheng;LIN Shuqian(Poulury Research Institute,Shandong Academy of Agricultural Sciences,Jinan 250100,China;Shandong Engineering Research Center for Animal Health Products,Jinan 250100,China;Shandong Senkang Sanfeng Biological Co.,Lid.,Jinan 250023,China;Shandong Xingu Health Industry Co.,Ltd,Binzhou 256600,China)

机构地区：[1]山东省农业科学院家禽研究所,山东济南250100 [2]动物保健品山东省工程研究中心,山东济南250100 [3]山东森康三峰生物有限公司,山东济南250023 [4]山东鑫谷健康产业有限公司,山东滨州256600

出　　处：《家禽科学》2023年第12期1-8,I0010,共9页Poultry Science

基　　金：山东省科技型中小企业创新能力提升工程项目(2023TSGC0006);山东省重大科技创新工程(2020CXGC010801);山东省科技成果转移转化补助(鲁渝协作)项目(2022);山东省重点研发计划(乡村振兴科技创新提振行动计划),编号2023TZXD083。

摘　　要：本试验旨在研究较长期摄入清营颗粒对大鼠的亚慢性毒性作用。选用80只SPF级SD大鼠,随机分为4组,每组20只(雌雄各半)。4组染毒剂量分别为0、5、10、20 g/kg体重的清营颗粒,连续给药30d。结果显示,10、20g/kg体重的清营颗粒对大鼠采食量、个别血液学指标及脏体比有一定影响,但未引起组织病理学变化。此外,5g/kg体重的清营颗粒对大鼠未表现明显的毒性作用。综上所述,清营颗粒对大鼠的无毒作用剂量(NOEL)为5 g/kg体重。This experiment aims to study the subchronic toxicity of Qingying Granules in rats after long-term intake.A total of 80 SPF-grade SD rats were randomly divided into four treatments with 20 rats per treatment(half male and half female).The four groups were exposed to Qingying Granules at doses of 0,5,10,and 20 g/kg body weight(BW)for 30 consecutive days by gavage.The results showed that Qingying Granules at doses of 10 and 20 g/kg BW had a certain impact on the feed intake,some hematological indicators and visceral body ratio,but did not cause histopathological changes in rats.Qingying Granules at a dose of 5 g/kg BW showed no significant toxic effects on rats.In summary,the non-toxic effect dose(NOEL)of Qingying Granules on rats was 5 g/kg BW.

关 键 词：清营颗粒 亚慢性毒性 大鼠 

分 类 号：S859.82[农业科学—临床兽医学]