医用^(99)Mo工业化生产技术研发  

Current Developments in the Industry Production Process of ^(99)Mo for Medical Use

作　　者：张建栋 陈真 陈雅宏 ZHANG Jiandong;CHEN Zhen;CHEN Yahong(Chengdu Xinke Pharmacy Co.,Sichuan Province,Chengdu 610200,China)

机构地区：[1]成都欣科医药有限公司,成都610200

出　　处：《同位素》2023年第6期620-632,共13页Journal of Isotopes

摘　　要：全球研究堆老化导致工业化生产^(99)Mo的靶辐照能力严重不足,以及核不扩散条约限制高浓铀的民用,迫使探索^(99)Mo新的生产工艺技术,并将现有的高浓铀靶向低浓铀靶转换,在新技术探索和靶转换的过程中,造成全球医用^(99)Mo供应短缺。美国、加拿大、欧洲等正在探索医用^(99)Mo商业化稳定供应的新工艺技术,如加速器粒子束、次临界装置、小堆、熔盐堆和溶液堆等辐照靶件,采用新材料和新工艺制备靶件,超临界、离子液体、新型色谱柱等应用于^(99)Mo的制备。低浓铀靶生产逐渐代替高浓铀靶,光核反应工艺已经成熟,低功率研究堆、次临界装置和粒子束等工艺可以解决部分本地放射性药物和核医学的需求,而加速器生产工艺研究活跃,是未来医用^(99)Mo生产的发展方向。The aging of global research reactors has led to a serious shortage of target irradiation capacity for industrial production of ^(99)Mo,as well as restrictions on the civilian use of high enriched uranium under the Nuclear Non Proliferation Treaty.This has forced the exploration of new production processes for ^(99)Mo and the conversion of existing high enriched uranium targets to low enriched uranium targets.In the process of exploring new technologies and target conversion,it has caused a global shortage of medical ^(99)Mo supply,endangering people’s health.The United States,Canada,and Europe are intensifying their exploration of new process technologies for the commercialization and stable supply of medical ^(99)Mo,such as exploring irradiation targets with as accelerator particle beams,subcritical devices,small reactors,molten salt stacks,and solution stacks,using new materials and processes to prepare targets,and applying supercritical,ionic liquids,and new chromatographic columns to the preparation of ^(99)Mo.The production of low enriched uranium targets is gradually replacing high enriched uranium targets.The photonuclear reaction process has matured,and processes such as low-power research reactors,subcritical devices,and particle beams can meet the needs of some local radioactive drugs and nuclear medicine.The active research on accelerator production technology is the development direction of future medical ^(99)Mo production.

关 键 词：^(99)Mo生产技术 ^(99)Mo分离 ^(99)Mo纯化 高比活度 ^(99)Mo/^(99m)Tc发生器 

分 类 号：TL99[核科学技术—核技术及应用]