妊娠期高血压患者血清APOC4、APOA1和FABP4变化及意义  

Changes and Significance of Serum APOC4,APOA1 and FABP4 in Patients with Hypertensive Disorder Complicating Pregnancy

作　　者：宋丽妞[1] SONG Liniu(Outpatient Department of the First Affiliated Hospital of Henan University of Science and Technology,Henan,Luoyang,471000,China)

机构地区：[1]河南科技大学第一附属医院门诊部,河南洛阳471000

出　　处：《实验与检验医学》2023年第4期408-411,424,共5页Experimental and Laboratory Medicine

摘　　要：目的探讨妊娠期高血压(HDCP)患者载脂蛋白C4(APOC4)、载脂蛋白A1(APOA1)和脂肪酸结合蛋白4(FABP4)的水平变化及临床意义。方法选取2018年1月至2021年1月我院收治的HDCP患者90例,根据中华医学会妊娠期高血压疾病诊治指南(2015)标准将其分为GH组(n=63)和PC组(n=27)。比较两组年龄、妊娠次数、孕前期体质量指数(BMI)等一般资料,采用化学发光法检测血清APOA1水平,采用酶联免疫吸附试验法(ELISA)检测患者FABP4和APOC4水平,采用干化学法测定患者24 h尿蛋白定量,Pearson相关性分析APOC4、APOA1和FABP4水平与HDCP患者病情严重程度关系。结果GH组与PC组年龄、妊娠次数、孕前期BMI、学历水平、家族史、睡眠时间、不良生活方式和家庭月收入等一般资料比较无显著差异(P>0.05)。GH组APOC4和FABP4显著低于PC组,APOA1显著高于PC组(P<0.05);GH组收缩压、舒张压和24 h尿蛋白定量显著低于PC组(P<0.05);APOC4与HDCP严重程度呈正相关(r=0.221,P<0.05),FABP4水平与HDCP严重程度呈正相关(r=0.215,P<0.05),APOA1与HDCP严重程度呈负相关(r=-0.252,P<0.05)。结论APOC4和FABP4与HDCP严重程度呈正相关,APOA1与HDCP严重程度呈负相关,临床可通过检测APOC4、FABP4和APOA1水平判断HDCP严重程度和预后恢复水平。Objective To explore the changes and clinical significance of apolipoprotein C4(APOC4),apolipoprotein A1(APOA1)and fatty acid binding protein 4(FABP4)in patients with hypertensive disorder complicating pregnancy(HDCP).Methods A total of 90 patients with HDCP admitted to the hospital were enrolled between January 2018 and January 2021.According to the criteria about Chinese Medical Association Guidelines for Diagnosis and Treatment of Gestational Hypertension(2015),they were divided into the GH group(n=63)and the PC group(n=27).The general data such as age,gravidity and progestational body mass index(BMI)between the two groups were compared.The level of serum APOA1 was detected by chemiluminescence method.Th levels of FABP4 and APOC4 were detected by enzyme-linked immunosorbent assay(ELISA).The 24 h urine protein quantification was detected by dry chemistry method.The relationship between APOC4,APOA1,FABP4 levels and the severity of HDCP was analyzed by Pearson correlation analysis.Results There was no significant difference the GH group and the PC group in age,gravidity,progestational BMI,educational level,family history,sleep time,poor lifestyles or family monthly income(P>0.05).The levels of APOC4 and FABP4 in the GH group were significantly lower than those in the PC group,while APOA1 level was significantly lower than that in the PC group(P<0.05).The systolic blood pressure,diastolic blood pressure and 24 h urine protein quantitative in the GH group were significantly lower than those in the PC group(P<0.05).APOC4 was positively correlated with the severity of HDCP(r=0.221,P<0.05),FABP4 was positively correlated with the severity(r=0.215,P<0.05),and APOA1 was negatively correlated with the severity(r=-0.252,P<0.05).Conclusion The levels of APOC4 and FABP4 are positively correlated with the severity of HDCP,while APOA1 level is negatively correlated with it.Clinically,APOC4,APOA1 and FABP4 can be applied to determine the severity of HDCP and prognosis recovery.

关 键 词：妊娠期高血压患者 血载脂蛋白A1 载脂蛋白C4 脂肪酸结合蛋白4 

分 类 号：R714.252[医药卫生—妇产科学]