芪参还五胶囊辅助治疗糖尿病合并冠心病的临床观察  

Clinical Observation of Qishenhuanwu Capsule(芪参还五胶囊)in Treating Diabetic Patients with Coronary Heart Disease

作　　者：吴琼 张贺翔 张美玉 韩露轩 程剑 赵辉[1] WU Qiong;ZHANG Hexiang;ZHANG Meiyu;HAN Luxuan;CHENG Jian;ZHAO Hui(Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou Hebei 061000,China)

机构地区：[1]河北省沧州中西医结合医院,河北沧州061000

出　　处：《中医药导报》2023年第11期94-98,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河北省中医药管理局科研计划项目(2020464,2021293)。

摘　　要：目的:观察芪参还五胶囊辅助治疗糖尿病合并冠心病的疗效及对患者糖脂代谢、血管内皮功能、血液流变学及炎症指标的影响。方法:将96例糖尿病合并冠心病患者随机分为观察组与对照组各48例。对照组给予冠心病二级预防及降低血糖药物治疗,观察组在对照组治疗的基础上给予芪参还五胶囊口服,单次口服2粒,每日3次,连续服用6周后比较两组患者的中医证候积分和临床疗效。比较两组患者治疗前后的血糖指标、血脂指标、血管内皮功能指标(VEGF、NO、ET-1)、血液流变学指标(全血高切/低切黏度、血浆黏度、FIB)及炎症指标(TNF-α、IL-6、IL-10、hs-CRP)水平。结果:观察组患者治疗后中医证候积分显著低于对照组(P<0.05);观察组总有效率显著高于对照组(P<0.05)。观察组患者治疗后的血糖指标、血脂指标、血管内皮功能指标、血液流变学指标及炎症指标均显著优于对照组(P<0.05)。结论:芪参还五胶囊辅助治疗糖尿病合并冠心病疗效确切,可显著改善临床症状,有利于调控糖脂代谢情况,改善血管内皮功能及血液流变学,并抑制炎症反应。Objective:To observe the curative effect of Qishenhuanwu capsule in treating diabetes mellitus complicated with coronary heart disease and its influence on glucose and lipid metabolism,vascular endothelial function,hemorheology and inflammatory indexes.Methods:A total of 96 patients with diabetes mellitus and coronary heart diseasewere included in the study,and were divided into observation group and control group according to random number table method,48 patients in each group.The control group was given secondary prevention of coronary heart disease and drugs to reduce blood glucose,and the observation group was additionally given Qishenhuanwu Capsule orally,2 capsules per time,3 times a day,on the basis of the treatment of the control group.After 6 weeks of continuous administration,the TCM syndrome scores and clinical efficacy of the two groups was compared.The blood glucose and lipid indexes,vascular endothelial function indexes(VEGF,NO,ET-1),hemorheology indexes(whole blood high/low shear viscosity,plasma viscosity,FIB)and inflammatory indexes(TNF-α,IL-6,IL-10,hs-CRP)were compared between the two groups before and after treatment.Results:The TCM syndrome score of the observation group was significantly lower than that of the control group(P<0.05).The effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the blood glucose indicators,blood lipid indicators,vascular endothelial function indicators,hemorheological indicators,and inflammatory indicators in the observation group were significantly better than those in the control group(P<0.05).Conclusion:Qishenhuanwu Capsule has definite curative effect in the treatment of diabetes complicated with coronary heart disease,which can significantly improve clinical symptoms,facilitate the regulation of glucose and lipid metabolism,improve vascular endothelial function and hemorheology,and inhibit inflammation.

关 键 词：糖尿病合并冠心病 芪参还五胶囊 糖脂代谢 血管内皮功能 血液流变学 炎症反应 临床研究 

分 类 号：R256.22[医药卫生—中医内科学]