慢性肾脏病矿物质和骨异常研究进展  

Advances of chronic kidney disease-mineral and bone disorder

作　　者：姚兰 王沛[1] Yao Lan;Wang Pei(Blood Purification Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院血液净化中心,郑州450052

出　　处：《中华肾脏病杂志》2023年第11期867-871,共5页Chinese Journal of Nephrology

基　　金：国家自然科学基金(82370747)。

摘　　要：慢性肾脏病(chronic kidney disease,CKD)矿物质和骨代谢异常(CKD-mineral and bone disorder,CKD-MBD)是CKD患者的常见并发症,严重影响其预后。CKD-MBD是慢性肾功能下降所引发的一系列矿物质和骨代谢异常综合征,临床表现主要为血钙升高或降低、血磷升高、全段甲状旁腺素升高、骨质疏松及血管钙化等。该文围绕高磷血症、继发性甲状旁腺功能亢进症、肾性骨病和血管钙化等基础和临床研究,综述其诊断、治疗和管理的研究进展。Chronic kidney disease(CKD)-mineral and bone disorder(CKD-MBD)is a common complication of CKD,which seriously affects the prognosis of patients.It is a series of abnormal mineral and bone metabolism syndrome caused by chronic renal function decline.The clinical manifestations are mainly decreased or increased serum calcium,increased serum phosphorus,increased intact parathyroid hormone,osteoporosis,and vascular calcification,etc.The paper reviews the research progress in the diagnosis,treatment and management based on the basic and clinical studies of hyperphosphatemia,secondary hyperparathyroidism,renal osteodystrophy and vascular calcification,etc.

关 键 词：慢性肾疾病-矿物质和骨代谢异常 高磷血症 甲状旁腺功能亢进症 继发性 肾性骨病 血管钙化 

分 类 号：R692[医药卫生—泌尿科学]