2022年国际儿科肾脏病学会儿童激素敏感型肾病综合征的诊断和管理临床实践指南解读及与2016年国内指南比较  

Interpretation of 2022 IPNA clinical practice recommendation for the diagnosis and management in children with steroid-sensitive nephrotic syndrome and comparison with 2016 guideline of China

作　　者：张沛 高春林 姚俊 夏正坤 Zhang Pei;Gao Chunlin;Yao Jun;Xia Zhengkun(Department of Paediatrics,Jinling Hospital,School of Medicine,Nanjing University,Nanjing 210002,China)

机构地区：[1]南京大学医学院附属金陵医院(东部战区总医院)儿科,南京210002

出　　处：《中华肾脏病杂志》2023年第11期872-878,共7页Chinese Journal of Nephrology

基　　金：江苏省自然科学基金-青年基金项目(BK20190251);中国博士后基金资助项目(2018M643888);江苏省博士后基金资助项目(2018K089B)。

摘　　要：复发是儿童肾病综合征(nephrotic syndrome,NS)的临床特征,部分激素敏感型NS(steroid-sensitive NS,SSNS)表现为频繁复发型NS和激素依赖型NS。激素的长期和频繁使用以及免疫抑制剂的不良反应,严重影响NS儿童的生活质量。2022年国际儿科肾脏病学会发布了儿童SSNS的诊断和管理临床实践指南。现结合中华医学会儿科学分会肾脏学组发布的《儿童激素敏感、复发/依赖NS诊治循证指南(2016)》(简称2016国内指南),对国际儿科肾脏病学会提出的SSNS临床治疗和管理建议进行解读,为儿童SSNS的诊治提供参考。Relapsing is the clinical characteristic of nephrotic syndrome(NS)in children,and some steroid-sensitive NS(SSNS)children have frequently relapsing NS and steroid-dependent NS.The long-term and frequent uses of glucocorticoids,as well as the adverse effects of immunosuppressants,seriously affect the quality of life in children with NS.The International Pediatric Nephrology Association released the clinical practice recommendation for SSNS in children in 2022.Based on the guideline for the diagnosis and treatment of steroid-sensitive,frequently-relapsing/dependent NS in children(2016)formulated by the Nephrology Group of Pediatrics Society of Chinese Medical Association,we interpreted the guideline on clinical treatment and management suggestions of SSNS,to provide references for the diagnosis and treatment of SSNS in children.

关 键 词：肾病综合征 糖皮质激素 儿童 诊疗指南 解读 

分 类 号：R726.9[医药卫生—儿科]