系统性免疫炎症指数与2型糖尿病患者异常心电图的相关性及其预测价值  

Study on the relationship between systemic immune-inflammation index and abnormal electrocardiogram in patients with type 2 diabetes

作　　者：马媛[1] 董蕴 汪京嘉 邵春丽 MA Yuan;DONG Yun;WANG Jingjia;SHAO Chunli(Department of Cardiology,Peking University Third Hospital,Beijing,100191,China)

机构地区：[1]北京大学第三医院心血管内科,北京100191

出　　处：《临床心血管病杂志》2023年第11期850-854,共5页Journal of Clinical Cardiology

基　　金：北京市自然科学基金(No:L223002)。

摘　　要：目的:探讨系统性免疫炎症指数(SII)与2型糖尿病患者(T2DM)异常心电图类型的相关性及预测T2DM患者异常心电图类型的价值。方法:回顾性纳入2022年1月—2023年4月在北京大学第三医院收治的436例T2DM患者作为研究对象。根据SII评分将患者分为SII低分组和SII高分组。采用多因素logistic回归分析SII与T2DM患者心电图异常之间的关系。同时,通过构建相关性及其预测价值模型(ROC)评估SII对T2DM患者心电图异常的预测价值。结果:相较于SII低分组,SII高分组患者出现心动过速(OR=2.44,95%CI:1.30~4.58,P=0.006)和ST-T改变(OR=1.75,95%CI:1.03~2.97,P=0.039)的风险增加;但SII与心动过缓、期前收缩、房室传导阻滞和心束支传导阻滞等心电图异常类型之间无关联性。进一步ROC分析显示,SII预测T2DM患者发生心动过速的曲线下面积为0.620(95%CI:0.538~0.720,P=0.005),预测ST-T改变的曲下面积为0.551(95%CI:0.475~0.628,P=0.039)。结论:SII与T2DM患者发生心动过速、ST-T改变有关,对T2DM发生心动过速、ST-T改变的诊断具有预测价值,可为T2DM患者心脏功能异常的预防提供参考。Objective:To investigate the correlation between systemic immuno-inflammatory index(SII) and abnormal electrocardiogram types in type 2 diabetes mellitus(T2DM) patients and the value of predicting abnormal ECG types in T2DM patients.Methods:A retrospective study was conducted on 436 T2DM patients from Peking University Third Hospital from January 2022 to April 2023.The patients were divided into the low SII group and high SII group using SII score.Logistic regression was used to explore the relationship between SII and the types of electrocardiogram abnormalities in T2DM patients.The diagnostic value of SII for the types of electrocardiogram abnormalities in T2DM patients was analyzed by constructing an ROC model.Results:Compared with the low SII group,patients in the high SII group had an increased risk of tachycardia(OR=2.438,95%CI:1.297-4.583,P=0.006) and ST-T changes(OR=1.749,95%CI:1.03-2.97,P=0.039).However,there was no statistically significant difference in bradycardia,premature contractions,atrioventricular block,and bundle branch block between the two groups.The ROC model revealed that the area under curves for SII predicting tachycardia were(95%CI:0.538-0.720,P=0.005) and ST-T changes(95%CI:0.475-0.628,P=0.039),respectively.Conclusion:SII is associated with the occurrence of tachycardia and ST-T changes in patients with T2DM,and has a predictive value for the diagnosis of tachycardia and ST-T changes occurring in T2DM,which may provide a reference for the prevention of cardiac function abnormalities in patients with T2DM.

关 键 词：2型糖尿病 系统性免疫炎症指数 心电图 心动过速 

分 类 号：R541.7[医药卫生—心血管疾病]