甲型H1N1流感后克莱恩-莱文综合征复发1例  

Recurrent attack of Kleine-Levin syndrome triggered by influenza A(H1N1):a case report

作　　者：胡思帆[1] 刘陈 孙伟[1] 孙洪强[1] Hu Sifan;Liu Chen;Sun Wei;Sun Hongqiang(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health,National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100191,China;The Second People′s Hospital of Dali Bai Autonomous Prefecture,Dali 671000,China)

机构地区：[1]北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100191 [2]大理州第二人民医院,大理671000

出　　处：《中华精神科杂志》2023年第6期457-460,共4页Chinese Journal of Psychiatry

摘　　要：克莱恩-莱文综合征(Kleine-Levin syndrome,KLS)是一种罕见病,表现为反复发作的嗜睡、认知障碍和行为改变,发作间歇期正常,感染是其发病的常见诱因。本文报道了1例在2023年3月我院收治的17岁首次发作,并在感染甲型H1N1流感病毒后再次复发的KLS患者。根据患者发作期出现的典型症状,发作间歇期无症状和体征,以及无其他诱因,患者诊断为继发于甲型H1N1流感后的KLS复发。本文旨在提示甲型H1N1流感可能是导致KLS复发的诱因,提示在KLS治疗中预防感染的重要性,以期引起临床医生注意。Klein-Levin syndrome(KLS)is a rare disease characterized by recurrent episodes of hypersomnia and cognitive and behavioral dysfunction.In addition,all functions remain intact during the intermittent period.Infection is a common risk factor for its onset.In this case,a 17-year-old patient with KLS was admitted to our hospital in March 2023 who first developed KLS symptoms and relapsed after being infected with influenza A Virus(H1N1).Based on the typical symptoms occurred during the patient′s attack,the absence of symptoms and signs during the interval,and the absence of other triggers,the patient was diagnosed with KLS recurrence secondary to influenza A Virus(H1N1).This case report aims to reveal that influenza A Virus(H1N1)may be contribute to the recurrence of KLS and that preventing infection is important in the treatment of KLS to draw the attention of clinical physicians.

关 键 词：流感病毒A型 H1N1亚型 克莱恩-莱文综合征 厌食 过度嗜睡性障碍 

分 类 号：R511.7[医药卫生—内科学] R749[医药卫生—临床医学]