Chrysophanol regulates AMPK/mTOR autophagy signal pathway to improve cognitive function in copper-laden rats with Wilson disease  

作　　者：张笑颜 ZHANG Xiaoyan(Sch Integr Chin&West Med,Anhui CM Univ,Hefei 230012)

机构地区：[1]Sch Integr Chin&West Med,Anhui CM Univ,Hefei 230012

出　　处：《China Medical Abstracts(Internal Medicine)》2023年第3期137-138,共2页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To study the neuroprotective effect of chrysophanol(CHR)on copper-laden rats with Wilson disease(WD),and explore its possible mechanism.Methods SD rats were randomly divided into 4 groups:control group(Control group),model group(Model group),low dose CHR group(CHR-L group),high dose CHRl group(CHR-H group),with 10 rats in each group.The model of copper-laden rats with WD were established by feeding copper containing(1 g/kg)feed and copper containing(0.185%)water for 12 weeks.

关 键 词：mechanism RATS protective 

分 类 号：R285.5[医药卫生—中药学]