精氨酸加压素在睡眠-觉醒及焦虑、抑郁情绪调控中的作用  

Role of arginine vasopressin in the regulation of sleep-arousal,anxiety and depression

作　　者：唐铭阳 陈长瑞[2] 朱亚楠 蔡李佳 张亚男(综述)[1] 王赞(审校)[1] TANG Mingyang;CHEN Changrui;ZHU Yanan(Department of Neurology,The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学白求恩第一医院神经内科,吉林长春130021 [2]上海复旦大学生命学院药理研究室,上海200233 [3]吉林省中医药科学院,吉林长春130022

出　　处：《中风与神经疾病杂志》2023年第11期1054-1056,共3页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金(82071489)。

摘　　要：精氨酸加压素(argininevasopressin,AVP),又称抗利尿激素,是由下丘脑视上核或室旁核分泌的高度保守的神经肽,具有复杂的生理功能。本文对AVP的生理学特性进行了简单概述,阐述AVP可能通过下丘脑泌素能系统和去甲肾上腺素能系统参与睡眠-觉醒调控,并通过促进视交叉上核神经元细胞间耦合来维持昼夜节律稳态;并描述了AVP在焦虑和抑郁情绪调控的可能作用。Arginine vasopressin(AVP),also known as antidiuretic hormone,is a highly conserved neuropeptide secreted by the supraoptic or paraventricular nucleus of the hypothalamus and has complex physiological functions.This article reviews the physiological properties of AVP and elaborates on the possible involvement of AVP in sleep-arousal regulation via the hypothalamic orexinergic and noradrenergic systems and the role of AVP in maintaining circadian homeostasis by facilitating intercellular coupling of suprachiasmatic nucleus neurons,as well as the potential role of AVP in the regulation of anxiety and depression.

关 键 词：精氨酸加压素 睡眠-觉醒 昼夜节律 焦虑 抑郁 

分 类 号：R338.63[医药卫生—人体生理学]