白扁豆花中酚酸类成分的分离与结构鉴定  

Isolation and identification of phenolic constituents from the flower bud of Dolichos lablab L.

作　　者：石中唯 张卫 刘薇[1] 阮静雅 王涛[1] 张祎[1] SHI Zhong-wei;ZHNAG Wei;LIU Wei;RUAN Jing-ya;WANG Tao;ZHANG Yi(Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学天津市中药化学与分析重点实验室,天津301617

出　　处：《中国药物化学杂志》2023年第11期857-863,共7页Chinese Journal of Medicinal Chemistry

基　　金：国家自然科学基金面上项目(82074118)。

摘　　要：目的对白扁豆花的酚酸类化学成分进行研究,明确其物质基础。方法应用硅胶、ODS及高效液相等多种色谱法对白扁豆花的提取物进行分离纯化,并主要通过核磁共振和质谱技术鉴定化合物的结构。结果从白扁豆花的70%(体积分数)乙醇提取物中分离鉴定了15个酚酸类成分,分别为原儿茶酸(1)、对羟基苯甲酸(2)、3-甲氧基-4-羟基苯甲酸(3)、咖啡酸(4)、顺式对羟基肉桂酸(5)、反式对羟基肉桂酸(6)、苯甲酸葡萄糖苷(7)、松香(8)、vanillic acid 4-O-β-D-glucoside(9)、2-羟基苄基-β-D-吡喃葡萄糖苷(10)、trans-p-coumaric acidβ-glucopyranoside(11)、反式对香豆酸-4-O-β-D-芹糖基(1″→2′)-O-β-D-吡喃葡萄糖苷(12)、4-O-β-D-吡喃葡萄糖基顺式苯丙烯酸(13)、4-O-β-D-芹糖基(1″→2′)-O-β-D-吡喃葡萄糖基顺式苯丙烯酸(14)、2-(sophorosyl)-1-(4-hydroxyphenyl)ethanone(15)。结论所有化合物均为首次从白扁豆花中分离得到,其中化合物7~14为首次从扁豆属植物中分离得到。Phytochemistry study for Dolichos lablab L.flower bud was investigated by using various chromatographic and spectroscopic methods,and fifeen phenolic acids named as protocatechuic acid(1),p-hydroxybenzoic acid(2),vanillic acid(3),caffeic acid(4),cis-4-hydroxycinnamic acid(5),trans-4-hydroxycinnamic acid(6),B-D-glucopyranosyl benzoate(7),rosin(8),vanillic acid 4-0βD-glucoside(9),2-hydroxybenzyl-B-D glucopyranoside(10),trans-p-coumaric acidβglucopyranoside(11),trans-p-coumaric acid4-O-B-D apiofuranosyl(1"→2')-0-B-D-glucopyranoside(12),4-0-B-D-glucopyranosyl phenylacrylic acid(13),4-0-p-D-apiofuranosyl(1"-→2')-O-B-D-glucopyranosyl phenylacrylic acid(14)and 2-(sophorosyl)-1-(4-hydroxyphenyl)ethanone(15),were obtained.All of them were gained from the flower bud of D.lablab for the first time.Among them,7-14 were firstly obtained from Dolichos genus.

关 键 词：白扁豆花 酚酸 分离与结构鉴定 

分 类 号：R284[医药卫生—中药学]