血清Periostin、ESM-1水平与冠心病患者心功能相关性分析  

Serum Periostin and ESM-1 Levels Are Correlated with Cardiac Function in Patients with Coronary Heart Disease

作　　者：杨晓青 王立美 王紫韫 王晓辉 李洁[1] 王小颖 YANG Xiaoqing;WANG Limei;WANG Ziyun;WANG Xiaohui;LI Jie;WANG Xiaoying(Department of Ultrasound,Shijiazhuang People's Hospital,Shijiazhuang,Hebei,050011,China)

机构地区：[1]石家庄市人民医院超声科,石家庄050011

出　　处：《中国分子心脏病学杂志》2023年第5期5628-5634,共7页Molecular Cardiology of China

基　　金：河北省医学科学研究课题计划项目(20201415)。

摘　　要：目的探讨冠心病(coronary heart disease,CHD)患者血清成骨细胞特异性因子2(Periostin)、内皮细胞特异性分子1(endothelial cell-specific molecule 1,ESM-1)水平与心功能指标的相关性。方法选择2020年9月至2022年5月收治的107例CHD患者作为观察对象(CHD组),其中男55例,女52例;年龄41~78(62.43±8.15)岁;根据美国纽约心脏学会(New York Heart Association,NYHA)分级,Ⅱ级42例,Ⅲ级36例,Ⅳ级29例;根据Gensini评分分为轻度组(<25分)42例,中度组(25~50分)35例,重度组(>50分)30例。选择同期健康体检人员(无心血管病史)110例为对照组。采用ELISA法检测血清Periostin和ESM-1水平,超声心动图检查心功能相关指标;Pearson分析CHD患者血清Periostin、ESM-1水平与心功能指标的相关性。结果CHD组患者LVEDD、LVESD、LAD、LVPW、LVMI、IVST及血清Periostin、ESM-1水平显著高于对照组(P<0.05),LVEF、FS、E/A、GLS显著低于对照组(P<0.05);心功能Ⅱ、Ⅲ、Ⅳ级患者LVEDD、LVESD、LAD、LVPW、LVMI、IVST及血清Periostin、ESM-1水平依次升高,而LVEF、FS、E/A、GLS水平依次降低(P<0.05);轻、中、重度冠状动脉狭窄的CHD患者血清Periostin、ESM-1水平比较,差异无统计学意义(P>0.05)。相关性分析结果显示,CHD患者血清Periostin、ESM-1水平与NT-proBNP、LVEDD、LVESD、LAD、LVPW、LVMI、IVST呈正相关(P<0.001),与LVEF、FS、E/A、GLS呈负相关(P<0.001)。结论CHD患者血清Periostin、ESM-1水平升高,与心功能指标相关,可能与患者的心脏结构变化有关。Objective To investigate the correlation between serum osteoblast-specific factor 2(Periostin)and endothelial cell-specific molecule 1(ESM-1)levels and cardiac function indexes in patients with coronary heart disease(CHD).Methods A total of 107 CHD patients admitted to our hospital from September 2020 to May 2022 were regarded as observation objects(CHD group).According to the New York Heart Association(NYHA)classification,42 cases were of gradeⅡ,36 cases were of gradeⅢ,and 29 cases were of gradeⅣ.According to Gensini score,42 cases were divided into mild group(<25 points),35 cases were moderate group(25-50 points)and 30 cases were severe group(>50 points).100 healthy people(without history of cardiovascular disease)were included as the control group.ELISA was used to detect the serum Periostin,ESM-1 levels.Echocardiography was used to examine cardiac function-related indicators.Pearson was used to analyze the correlation between serum Periostin and ESM-1 levels and cardiac function indexes in CHD patients.Results The levels of LVEDD,LVESD,LAD,LVPW,LVMI,IVST and serum Periostin and ESM-1 in CHD group were significantly higher than those in control group(P<0.05),and the levels of LVEF,FS,E/A and GLS were significantly lower than those in control group(P<0.05).The levels of LVEDD,LVESD,LAD,LVPW,LVMI,IVST and serum Periostin and ESM-1 were increased successively in patients with cardiac function gradeⅡ,ⅢandⅣ,while the levels of LVEF,FS,E/A and GLS were decreased successively(P<0.05).There was no significant difference in serum Periostin and ESM-1 levels in CHD patients with mild,moderate and severe coronary artery stenosis(P>0.05).Correlation analysis showed that serum Periostin,ESM-1 level in CHD patients was positively correlated with NTproBNP,LVEDD,LVESD,LAD,LVPW,LVMI and IVST(P<0.001),and negatively correlated with LVEF,FS,E/A and GLS(P<0.001),and was not correlated with TC,TG,HDL-C,LDL-C and Gensini scores(P>0.05).Conclusion Serum Periostin and ESM-1 levels in CHD patients are elevated,which are rel

关 键 词：冠心病 成骨细胞特异性因子2 内皮细胞特异性分子1 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]