聚乙二醇修饰引发的加速血液清除效应及其应对策略  

Accelerated blood clearance effect by polyethylene glycol modification and its countermeasures

作　　者：车俊玮 邹鹏飞 李珂 高春生 刘彩红 李志平[2] CHE Junwei;ZOU Pengfei;LI Ke;GAO Chunsheng;LIU Caihong;LI zhiping(School of Pharmaceutical Sciences&Institute of Materia Medica,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,Shandong,China;Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]山东第一医科大学药学院(药物研究所),济南250117 [2]军事科学院军事医学研究院毒物药物研究所,北京100850

出　　处：《军事医学》2023年第10期788-792,共5页Military Medical Sciences

基　　金：国家重点研发计划(2022YFC2604000)。

摘　　要：近年来,聚乙二醇(PEG)作为一种高分子聚合物,在纳米药物递送方面应用广泛;PEG化修饰是实现纳米制剂长循环的“金标准”。然而,加速血液清除(ABC)效应限制了PEG化策略的进一步发展,是PEG修饰纳米载体面临的重要挑战之一。因此,探讨ABC效应及其应对策略对PEG化具有重要意义。该文探讨了ABC的作用机制及影响因素,综述了改善ABC效应的策略及研究进展。同时,也对PEG化及克服ABC效应策略进行了总结与展望,以期为此方向的研究提供一定的参考。Polyethylene glycol(PEG),a high polymer,is widely used in the delivery of drugs to modify different types of carriers.Pegylation is considered as the“gold standard”for the long circulation of nano⁃preparations.However,subsequent research finds that PEGylated liposomes were rapidly cleared in the blood and accumulated in the liver after repeated administration in rats,which is known as the accelerated blood clearance(ABC)effect.ABC poses a major challenge to PEGylated nanocarriers.Therefore,modifying the structure of PEG or finding new modification methods to replace PEG can be good solutions.This paper reviews the research progress in ABC effect in recent years.

关 键 词：聚乙二醇 加速血液清除效应 纳米载体 药物递送 长循环 

分 类 号：R969[医药卫生—药理学]