Two new phenolic amides from Allium chinense  

作　　者：Xiaoqing Li Shikai Yan Jihong Lu Rui Wang Xianpeng Ma Xue Xiao Yan Zhang Huizi Jin 

机构地区：[1]Department of Natural Product Chemistry,School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China [2]Institute of Chinese Medicinal Sciences,Guangdong Pharmaceutical University,Guangzhou 510006,China [3]Guizhou Jingcheng Pharmaceutical Co.,Ltd.,Guiyang 550200,China

出　　处：《Chinese Herbal Medicines》2023年第4期603-606,共4页中草药（英文版）

基　　金：supported by Natural Science Foundation of China (No. 81973191);Shanghai Natural Science Fund (No. 19ZR1428100);project supported by the Department of Science and Technology of Guizhou (No. [2018] 2831);the Horizontal Research Project of Shanghai Jiao Tong University (Nos. SA1700111, SA1700118)。

摘　　要：Objective: To isolate the phenolic amides from the dried bulbs of Allium chinense and investigate their myocardium protective activities.Methods: The chemical constituents were isolated and purified by combining with silica gel column,Sephadex LH-20 column, HPLC and other chromatography techniques. Their structures were elucidated by NMR techniques and mass spectrometry. The isolated compounds were evaluated to determine their protective effect for myocardium cells in vitro.Results: Two new phenolic amides, namely, alichinemide Ⅰ(1) and alichinemide Ⅱ(2), and six konwn amides were isolated from the dried bulbs of A. chinense. The structures of compounds 3–8 were identified as 3-indolcarbaldehyde(3), 1-(2-aminophenyl)urea(4), 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid(5), N-trans-feruloyltyramine(6), N-trans-p-coumaroyltyramine(7), and N-(3,4-dimethoxyphenethyl) acetamide(8). Compound 3(50 μmol/L) showed significant inhibitory effect on the damage of H9c2 myocardial cells induced by H2O2in vitro.Conclusion: Compounds 1 and 2 were new phenolic amides. Compound 3 could be one of the potential myocardium protective constituents of A. chinense.

关 键 词：alichinemideⅠ alichinemideⅡ Allium chinense 3-indolcarbaldehyde myocardium protective activities phenolic amides 

分 类 号：R284.1[医药卫生—中药学]