硫氧还蛋白-1:预防心脏相关活性氧损伤的潜在靶点  

Thioredoxin-1:A potential target for prevention of heart-related reactive oxygen species injury

作　　者：孙伊人 杨子琪 王欣然 钱永军[1] SUN Yiren;YANG Ziqi;WANG Xinran;QIAN Yongjun(Department of Cardiovascular Surgery,West China Hospital,Sichuan University,Chengdu,610041,P.R.China;West China School of Medicine,Sichuan University,Chengdu,610041,P.R.China;West China School of Stomatology,Sichuan University,Chengdu,610041,P.R.China)

机构地区：[1]四川大学华西医院心脏大血管外科,成都610041 [2]四川大学华西临床医学院,成都610041 [3]四川大学华西口腔医学院,成都610041

出　　处：《中国胸心血管外科临床杂志》2023年第12期1779-1783,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：四川大学华西医院学科卓越发展1·3·5工程临床研究孵化项目(2019HXFH029);四川省卫生健康委员会医学科技项目(21PJ035);四川省干部保健科研课题(川干研2023-116);四川省中医药管理局中医药科研专项课题(2023MS439)。

摘　　要：活性氧(reactive oxygen species,ROS)可导致细胞凋亡进而引发器质性疾病,损伤心脏功能,在多种心脏疾病的发生中起重要作用。虽然抗ROS疗法备受期待,但目前仍缺乏公认理想的方案以预防ROS损伤。作为重要的内源性抗氧化系统之一,硫氧还蛋白(thioredoxin,Trx)被证明具有出色的抗氧化活性。通过不同方法激动Trx-1活性,能还原关键生物分子,或清除ROS,或调节众多细胞生存相关信号通路,抵抗ROS损伤。本文就Trx-1在心脏抗氧化治疗中的研究进展作一综述,以探讨Trx-1作为抵抗ROS损伤靶点的潜力与可能性。Reactive oxygen species(ROS)play an important role in the pathogenesis of various cardiovascular diseases,by leading to cell apoptosis and thus causing organic injuries.Anti-ROS therapy is highly anticipated,but currently,there is still no appropriate prevention method.Studies have shown that thioredoxin(Trx),being a kind of significant endogenous antioxidant system,has excellent antioxidant capacity.Promotion of Trx can reduce key biomolecules to eliminate ROS or regulate many signaling pathways,thus resisting ROS injuries,which may be a new antiROS strategy.Therefore,we reviewed the research progress of Trx in cardiac antioxidant therapy to discuss its potential and possibility to be a target for prevention of heart-related ROS injury.

关 键 词：活性氧 氧化应激 硫氧还蛋白 抗氧化 综述 

分 类 号：R54[医药卫生—心血管疾病]