缺铁性贫血的现代认识与治疗进展  

Diagnosis and treatment of iron deficiency anemia:modern understanding

作　　者：张凤奎[1] ZHANG Fengkui(Anemia Therapeutic Centre,State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,300020,Tianjin,China)

机构地区：[1]中国医学科学院,北京协和医学院,血液学研究所,血液病医院贫血治疗中心,实验血液学国家重点实验室,国家血液系统疾病临床医学研究中心,海河实验室,天津300020

出　　处：《临床血液学杂志》2023年第11期763-767,共5页Journal of Clinical Hematology

摘　　要：缺铁性贫血(iron deficiency anemia,IDA)是最常见的贫血类型,铁缺乏患者即使尚未发生贫血也可表现出组织细胞铁缺乏的相关症状,导致严重后果。血清铁蛋白<15μg/L表明机体储存铁已然耗竭,而<30μg/L通常认为储存铁即已明显减低。IDA铁剂治疗也受到铁稳态调节影响。选择合适的一线补铁治疗方法的关键是识别出不适于口服补铁的患者。血清铁调素水平与口服铁剂吸收呈负相关,口服铁剂治疗IDA应避免每日多次给药,IDA现代静脉补铁治疗更为安全、有效。Iron deficiency anemia is the most common type of anemia.Iron deficiency,even in the absence of anemia,can be debilitating,and exacerbate any underlying chronic disease.A serum ferritin<30μg/L is generally considered to have significantly reduced iron storage,while<15μg/L indicates that the body has depleted iron stores.Iron replacement therapy is affected by iron homeostasis regulation.The key to choosing appropriate first-line iron therapy is to identify patients who are not candidates for oral iron supplementation.Serum hepcidin levels are inversely correlated with oral iron absorption,and multiple daily doses should be avoided for oral iron therapy.Modern intravenous iron therapy is safer and more effective.

关 键 词：贫血 铁缺乏 诊断 补铁治疗 

分 类 号：R556.3[医药卫生—血液循环系统疾病]