INHB水平在预测宁夏及其周边地区男性睾丸生精功能中的作用  

Value of serum INHB in evaluating testicular spermatogenesis function of the male patients in Ningxia and its surrounding areas

作　　者：景万红[1,2] 袁莹莹[1,2] 宋晓霞 陈耀平[1,2] 哈灵侠[1,2] 刘春莲[1,2] 贾韶彤[1,2] Jing Wanhong;Yuan Yingying;Song Xiaoxia;Chen Yaoping;Ha Lingxia;Liu Chunlian;Jia Shaotong(The Center for Reproductive Medicine,General Hospital of Ningxia Medical University,YinChuan 750000,Ningxia,China;Key Laboratory of Fertility Preservation and Maintenance of Ningxia Medical University,Ministry of Education,Yinchuan 750004,Ningxia,China)

机构地区：[1]宁夏医科大学总医院生殖医学中心,宁夏银川750000 [2]宁夏医科大学生育力保持教育部重点实验室,宁夏银川750004

出　　处：《中国男科学杂志》2023年第5期63-68,共6页Chinese Journal of Andrology

基　　金：妇产创新平台与重点专科开放课题(Y2020003)。

摘　　要：目的探讨宁夏及其周边地区不同睾丸生精功能患者血清中抑制素-B(inhibin-B,INHB)水平,进一步明确其与患者年龄、睾丸体积、血清性激素的关系,并分析INHB对睾丸生精功能的评估价值。方法收集2019年1月至2020年12月就诊于宁夏医科大学总医院生殖医学中心的不孕不育患者1730例,依据精液检查结果及手术取精结局分组,分为正常精子组1493例、轻度少精子组55例、中度少精子组14例、重度少精子组52例、梗阻性无精子症组51例、非梗阻性无精子症组65例。比较各组睾丸体积及血清INHB、卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、睾酮(testosterone,T)水平;采用折线图分析患者年龄与INHB的关系;采用Pearson法分析患者睾丸体积及血清性激素水平与INHB的相关性;采用受试者工作特征(receiver operating characteristic curve,ROC)曲线分析血清FSH、INHB及睾丸体积对睾丸生精功能评估的意义。结果各组左侧和右侧睾丸体积、血清INHB、FSH、LH、T水平比较,差异有统计学意义(P<0.05)。正常精子组和少精子组患者年龄与血清INHB水平均呈倒U型分布,31~40岁间血清INHB水平达峰后随着年龄增长而呈下降趋势。所有患者左右侧睾丸体积与血清INHB水平均呈正相关性(P<0.05);正常精子组和少精子组患者血清FSH、LH、T与INHB水平均呈正相关性(P<0.05)。血清FSH、INHB及睾丸体积联合评估睾丸生精功能的曲线下面积为0.908,灵敏度为70.4%,特异度为92.5%。结论睾丸体积及血清INHB、FSH三项指标对于评估睾丸生精功能均有意义,三者联合的评估价值更高。Objective To analyze serum inhibin-B(INHB)levels in patients with different testicular spermatogenic functions in Ningxia and its surrounding areas,and clarify its relationship with patient age,testicular volume and serum hormones,as well as determine the value of serum INHB in evaluating testicular spermatogenic function.Methodss A total of 1730 infertile patients who visited the Reproductive Medicine Center of Ningxia Medical University General Hospital from January 2019 to December 2020 were enrolled in the study.The patients were divided into normal sperm group(1493 cases),mild oligospermia group(55 cases),moderate oligospermia group(14 cases),severe oligospermia group(52 cases),obstructive azoospermia group(51 cases),and non obstructive azoospermia group(65 cases)based on semen examination results and surgical sperm retrieval results.The testicular volume and serum levels of INHB,follicle stimulating hormone(FSH),luteinizing hormone(LH),and testosterone(T)in each group were comparatively analyzed;a line graph was used to analyse the relationship between patient age and INHB;the Pearson method was used to compare the correlation between testicular volume,serum hormone levels,and INHB in patients;The significance of serum FSH,INHB,and testicular volume in evaluating testicular spermatogenic function were analyzed using receiver operating characteristic curve(ROC)curve.Results There were significant differences in left and right testicular volume,serum INHB,FSH,LH,and T levels among each group(P<0.05).The age and serum INHB levels of patients in the normal sperm group and oligospermia group showed an inverted U-shaped distribution,and the serum INHB levels peaked between the ages of 31 and 40 and showed a decreasing trend with age.The volume of the left and right testicles in all patients showed a positive correlation with serum INHB levels(P<0.05);the levels of serum FSH,LH,T,were all positively corelated with the level of serum INHB in both the normal sperm group and oligosperm group(P<0.05).The area under th

关 键 词：抑制素B 生精功能 无精子症 睾丸 

分 类 号：R446.1[医药卫生—诊断学] R698.2[医药卫生—临床医学]