为什么氯胺酮应向艾司氯胺酮转型升级?  

Why ketamine should be upgraded to S+ketamine?

作　　者：赵薇[1] 邓硕曾[2] Zhao Wei;Deng Shuozeng(Department of Pharmacy,Dongfang Hospital Beijing University of Chinese Medicine,Beijing City 100078,China;Department of Anesthesiology,Dongfang Hospital Beijing University of Chinese Medicine,Beijing City 100078,China)

机构地区：[1]北京中医药大学东方医院药学部,北京100078 [2]北京中医药大学东方医院麻醉科,北京100078

出　　处：《中华疼痛学杂志》2023年第5期743-744,共2页Chinese Journal Of Painology

摘　　要：氯胺酮是左旋(R-)和右旋(S+)的混合消旋体。艾司(S+)氯胺酮是氯胺酮纯右旋镜像体, 主要作用为镇痛和麻醉。艾司氯胺酮强度是氯胺酮的两倍, 且不良反应少。趋利避害, 艾司氯胺酮应取代氯胺酮, 用于危重休克患者的镇痛和麻醉, 尤其是血液动力学不稳定者。艾司氯胺酮也是战时和抗灾不可缺少的药物。Ketamine is a racemic mixture of(R-)and(S+)isomers.S+ketamine,the pure dextrorotatory enantiomer of ketamine,mainly has an effect on analgesia and anesthesia,and is twice as potent as ketamine with fewer adverse reactions.S+ketamine should replace ketamine in order to seek the advantages and avoid disadvantages,for critically ill shock patients,especially for the wounded with hemodynamically unstable.S+ketamine is also an indispensable medicine in wartime and disaster relief.

关 键 词：氯胺酮 艾司氯胺酮 转型升级 危重患者 

分 类 号：R971.2[医药卫生—药品]