苗药痛风灵对湿热痹阻型急性痛风性关节炎疗效及对细胞因子水平的影响  

Effect of Miao Medicine Tongfengling on Acute Gouty Arthritis of Damp-Heat Obstruction Type and its Effect on Cytokine Level

作　　者：傅汝刚 程志刚 顾春松 雷豫 Fu Rugang;Cheng Zhigang;Gu Chunsong;Lei Yu(Guizhou University of Chinese Medicine,Guiyang 550002,China;The Second Hospital Affiliated to Guizhou University of Chinese Medicine,Guiyang 550003,China)

机构地区：[1]贵州中医药大学,贵州贵阳550002 [2]贵州中医药大学第二附属医院,贵州贵阳550003

出　　处：《亚太传统医药》2023年第12期98-102,共5页Asia-Pacific Traditional Medicine

基　　金：学科建设青年教师及研究生课题(贵州中医药大学骨伤学科资助1号合同);贵州中医药大学研究生教育创新计划项目(YCXZR2020012)。

摘　　要：目的:探讨苗药痛风灵治疗湿热痹阻型急性痛风性关节炎的疗效。方法:收集60例贵州中医药大学第二附属医院就诊的患者,随机分为治疗组(30例)和对照组(30例)。对照组予以依托考昔片+碳酸氢钠片,治疗组在对照组基础上再口服苗药痛风灵,记录治疗前及治疗后患者中医证候积分、视觉模拟评分法(VAS评分)、实验室指标,并将各组数据行统计学分析。结果:两种方案均能降低中医证候积分和VAS评分,差异具有统计学意义(P<0.05);且治疗组优于对照组,差异具有统计学意义(P<0.05)。两组治疗前后实验室指标均有不程度降低,差异具有统计学意义(P<0.05);且治疗组对实验室指标的影响总体优于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后临床疗效比较,治疗组总有效率93.33%,对照组总有效率86.67%,差异具有统计学意义(P<0.05)。安全性评价:在规范治疗期间,治疗组与对照组的患者并没有出现不良事件。结论:苗药痛风灵联合西药治疗湿热痹阻型急性痛风性关节炎,能有效缓解患者疼痛,减轻关节肿胀,恢复关节功能,还能有效降低尿酸水平,以及控制实验室炎症指标,安全有效,值得临床推广。Objective:To explore the curative effect of Miao Medicine Tongfengling on acute gouty arthritis with damp-heat stagnation.Methods:Sixty orthopedic patients from the Second Affiliated Hospital of Guizhou University of Chinese Medicine were randomly divided into treatment group(30 cases)and control group(30 cases).The control group was given etoricoxib tablets and sodium bicarbonate tablets,while the treatment group was given Miao Medicine Tongfengling,on the basis of the control group.The TCM syndrome score,visual analogue scale(VAS)and laboratory indexes of patients before and after treatment were recorded,and the data of each group were statistically analyzed.Results:Both schemes can reduce TCM syndrome score and VAS score,and the difference is statistically significant(P<0.05).And the treatment group was better than the control group,with statistical significance(P<0.05).Before and after treatment,the laboratory indexes of the two groups decreased to some extent,and the difference was statistically significant(P<0.05).Moreover,the influence of the treatment group on the laboratory indexes was better than that of the control group,with statistical significance(P<0.05).Comparing the clinical efficacy of the two groups after treatment,the total effective rate was 93.33%in the treatment group and 86.67%in the control group,with statistical significance(P<0.05).Safety evaluation:During the standardized treatment,there were no adverse events in the patients in the treatment group and the control group.Conclusion:Miao Medicine Tongfengling combined with western medicine can effectively relieve patients'pain,relieve joint swelling and restore joint function,and can also effectively reduce uric acid level and control laboratory inflammatory indicators,which is safe and effective and worthy of clinical promotion.

关 键 词：急性痛风性关节炎 湿热痹阻 苗药痛风灵 临床研究 

分 类 号：R29[医药卫生—民族医学] R259[医药卫生—中医学]