中医药对肠癌术后胃肠功能紊乱恢复用药规律研究  

Study on the Rule of Traditional Chinese Medicine in the Recovery of Gastrointestinal Dysfunction After Colorectal Cancer Surgery

作　　者：杨新玉 杨会举[2] 周凤蕊[2] 卢玉阳 赵允阳 孙浩格 张苗 Yang Xinyu;Yang Huiju;Zhou Fengrui;Lu Yuyang;Zhao Yunyang;Sun Haoge;Zhang Miao(College of Acupuncture and Tuina,Henan University of Chinese Medicine,Zhengzhou 450046,China;The Third Hospital Affiliated to Henan University of Chinese Medicine,Zhengzhou 4500o8,China)

机构地区：[1]河南中医药大学针灸推拿学院,河南郑州450046 [2]河南中医药大学第三附属医院,河南郑州450008

出　　处：《亚太传统医药》2023年第12期170-175,共6页Asia-Pacific Traditional Medicine

基　　金：河南省中医药拔尖人才项目(豫卫中医函[2021]15号);河南省科技攻关项目(222102310417);河南省中医药科学研究专项课题项目(20-21ZY2076)。

摘　　要：目的:通过数据挖掘探析中药治疗肠癌术后胃肠功能紊乱的用药规律。方法:通过检索建库至2022年12月1日中国知网(CNKI)、万方、维普数据库(VIP)中关于中药治疗肠癌术后胃肠功能紊乱的相关文献,筛选处方建立数据库,使用中医药传承计算平台V3.0软件将数据库中的中药进行频数、四气五味、归经功效分析,再使用SPSS Modeler 18.0和SPSS Statistics 21.0软件进行数据的高频用药关联规则分析和聚类分析。结果:通过筛选,符合标准的文献共有102篇,涉及处方73首,涉及中药141味,用药频次位居前五的中药有白术、炙甘草、茯苓、黄芪、党参;以补虚类、理气类、利水渗湿类药物为主;药性以温、平性为主;药味以甘、苦、辛居多;归经主要以脾经、肺经、胃经为主;关联规则分析,获取二项关联药物12组,三项关联药物12组,聚类分析获取到3个聚类处方。结论:中医药对肠癌术后胃肠功能紊乱的恢复多以健脾益气、扶正补虚、行气通腑、通络散瘀、和胃化湿为主要治疗原则,在此基础上进行遣方用药,可为临床的诊疗提供一定的借鉴。Objective:To explore the rule of drug use of traditional Chinese medicine in treating gastrointestinal dysfunction after colorectal cancer surgery through data mining.Methods:By searching the relevant literatures about the treatment of gastrointestinal dysfunction by traditional Chinese medicine in the databases of CNKI,WanFang and VIP from the date of establishment of the database to December 1,2022,the database was established by screening the prescriptions,and the traditional Chinese medicine in the database was analyzed by using the V3.0 software of traditional Chinese medicine inheritance calculation platform on frequency,four Qi and five flavors,and meridian tropism,SPSS Modeler 18.0 and SPSS Statistics 21.0 software were used to analyze the association rules and cluster analysis of high-frequency drug use data.Results:Through screening,there were 102 articles that met the standard,involving 73 prescriptions and 141 Chinese herbs.The top five Chinese herbs in terms of medication frequency were Atractylodes macrocephala,Roasted licorice,Poria cocos,Astragalus membranaceus and Codonopsis pilosula;The drugs mainly include those for tonifying deficiency,regulating Qi,and promoting water and moisture;The drug properties are mainly warm and flat;The medicine tastes sweet,bitter and bitter;Channel tropism mainly includes spleen,lung and stomach meridians;Association rule analysis obtained 12 second-order drug pair associations,12 third-order associations,and cluster analysis obtained 3 cluster prescriptions.Conclusion:The recovery of gastrointestinal dysfunction after colorectal cancer surgery by traditional Chinese medicine is mainly based on the principles of invigorating the spleen and qi,strengthening the vital energy and tonifying the deficiency,promoting qi and activating the fu organs,unblocking collaterals and removing blood stasis,and resolving dampness in the stomach.On this basis,prescription and medication can provide some reference for clinical diagnosis and treatment.

关 键 词：数据挖掘 中医药 肠癌术后 胃肠功能紊乱 用药规律 

分 类 号：R269[医药卫生—中西医结合]