妊娠期急性脂肪肝患者术后并发症的危险因素  

Risk factor for postoperative complications in patients with acute fatty liver during pregnancy

作　　者：陈伟明[1] 梁佩雯 王寿平[1] Chen Weiming;Liang Peiwen;Wang Shouping(Department of Anesthesiology,Guangzhou Medical Center for Critical Pregnant Women,the Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China;Department of Anesthesiology,the Third Affiliated Hospital of Guangzhou University of Chinese Medical,Guangzhou 510375,China)

机构地区：[1]广州医科大学附属第三医院麻醉科,广州510150 [2]广州中医药大学第三附属医院麻醉科,广州510375

出　　处：《中华麻醉学杂志》2023年第10期1170-1172,共3页Chinese Journal of Anesthesiology

基　　金：广东省科技厅基础与应用基础面上项目(2021A1515220002);广州市2023卫生健康委临床特色技术建设项目(2023C-TS55)。

摘　　要：目的筛选妊娠期急性脂肪肝患者术后并发症的危险因素。方法收集2016年1月至2023年4月医院收治的妊娠期急性脂肪肝患者病历资料,包括一般情况、临床症状、实验室检查、并发症等。根据患者是否发生术后并发症分为术后并发症组和未发生术后并发症组,采用logistic回归分析法筛选妊娠期急性脂肪肝患者术后并发症的危险因素。结果61例患者中,发生术后并发症26例,发生率为43%。2组初产妇比率、黄疸比率、凝血酶原时间、活化部分凝血活酶时间、丙氨酸氨基转移酶、总胆红素、直接胆红素和血清肌酐浓度比较差异有统计学意义(P<0.05)。logistic回归分析结果显示,初产妇、凝血酶原时间和血清肌酐浓度是发生术后并发症的危险因素(P<0.05)。结论初产妇、凝血酶原时间和血清肌酐浓度是妊娠期急性脂肪肝患者发生术后并发症的危险因素。Objective To identify the risk factors for postoperative complications in the patients with acute fatty liver during pregnancy.Methods The medical records from patients with acute fatty liver during pregnancy admitted to the hospital from January 2016 to April 2023,including baseline characteristics,clinical symptoms,laboratory examinations,complications,etc.were collected.Patients were divided into postoperative complication group and non-postoperative complication group according to whether the patients developed postoperative complications,and logistic regression analysis was used to identify the risk factors for postoperative complications in the patients with acute fatty liver during pregnancy.Results A total of 61 patients were included in this study,26 patients developed postoperative complications,and the incidence was 43%.There were significant differences in the ratio of primigravida,ratio of jaundice,prothrombin time,activated partial thromboplastin time,alanine aminotransferase,total bilirubin,direct bilirubin,and serum creatinine concentrations between the two groups(P<0.05).The results of logistic regression analysis showed that primigravida,prothrombin time and serum creatinine concentrations were risk factors for postoperative complications(P<0.05).Conclusions Primigravida,prothrombin time and serum creatinine concentrations are risk factors for postoperative complications in the patients with acute fatty liver during pregnancy.

关 键 词：孕妇 脂肪肝 手术后并发症 危险因素 

分 类 号：R714.255[医药卫生—妇产科学]