自组装肽RADA16及其衍生物用于药物递送的研究进展  

Progress in using the self-assembled peptide RADA16 and its derivatives for drug delivery

作　　者：李春苗 梁冰馨 唐铭 汪磊 杨建 廖洪利[1] LI Chunmiao;LIANG Bingxin;TANG Ming;WANG Lei;YANG Jian;LIAO Hongli(School of Pharmacy,Chengdu Medical College,Sichuan Chengdu 610500,China;Oncology Hematology Department,Chengdu Pidu District People's Hospital,Sichuan Chengdu 611730,China)

机构地区：[1]成都医学院药学院,四川成都610500 [2]成都市郫都区人民医院肿瘤血液科,四川成都611730

出　　处：《中国医院药学杂志》2023年第22期2589-2593,2598,共6页Chinese Journal of Hospital Pharmacy

基　　金：成都市重点研发项目(编号:2022-YF05-01379-SN);成都医学院学科创新团队项目(编号:CMC-XK-2104);成都医学院-成都市郫都区人民医院联合科研基金项目(编号:2021LHZD-05)。

摘　　要：自组装肽RADA16具有两亲性,可与不同类型的药物相互作用,其在生理条件下自发组装形成含水量超过99%的纳米纤维网格结构,模拟体内细胞外基质的孔隙度和结构,不仅为细胞提供适宜生长的微环境、促进受损组织的修复与重建,还具有良好的载药能力;当RADA16的C端或N端被特定的功能肽修饰时,既保留RADA16原有的功能,又使RADA16自组装水凝胶具有更强大的功能。该文综述了基于离子互补型自组装肽RADA16在药物传递领域的研究进展,探讨了基于RADA16及其衍生物的载药系统在生物医学中的应用前景和研究方向。The amphiphilic nature of self-assembled peptide RADA16 enables it to interact with different types of drugs;the self-assembly characteristics spontaneously assemble to form a nanofiber grid structure with water content exceeding 99%under physiological conditions,simulating the porosity and structure of the extracellular matrix,which not only provides suitable microenvironment for cells and promotes the repair and reconstruction of damaged tissues,but also have good drug loading capacity,and when the C or N terminal of RADA16 is modified by specific functional peptide,the original function of RADA16 is retained,and the RADA16 self-assembled hydrogel has more powerful function.In this review,we review the progress of ion-based self-assembled peptide RADA16 in the field of drug delivery,and explore the application prospects and research directions of drug loading systems based on RADA16 and its derivatives in biomedicine.

关 键 词：自组装肽 RADA16 药物递送 组织修复 水凝胶 

分 类 号：R944[医药卫生—药剂学]