Scale-up Efficient Synthesis of α-Poly(L-lysine)  

作　　者：Wenxiu Lv Maosheng Li Youhua Tao 

机构地区：[1]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Renmin Street 5625,Changchun,Jilin,130022 China [2]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei,Anhui,230026 China

出　　处：《Chinese Journal of Chemistry》2023年第19期2488-2492,共5页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(91856113 and U21A2089);the National Key Research and Development Program of China(2022YFE0130500).

摘　　要：α-Poly(_(L)-lysine)(α-PLL)is a water-soluble cationic biopolymer containing the monomeric unitα-_(L)-lysine,which not only possesses excellent intrinsic properties but also can be modified via facile reactions between the side amine groups and many other functional moieties.Ring-opening polymerization(ROP)is the most prevalently used technique for the synthesis of PL_(L)-based polypeptides,which involves initial conversion of theε-primary amine-protectedα-_(L)-lysine to the _(L)-lysine NCA monomer.However,obtaining N-carboxyanhydrides(NCAs)in high purity has been a formidable challenge for over 50 years,let alone the large-scale synthesis.Herein,we show an unprecedented scale-up synthesis of _(L)-Cbz-LysNCA monomer and its polymers,generating linearα-poly(_(L)-lysine)with molecular weight(MW)up to 13.4 kDa.This easy operated scale-up strategy will lay the foundations for the industrial preparation of _(L)-Cbz-LysNCA and its polymers,and further extend the realm of existing applications,offering a paradigm for scale-up synthesis of other polypeptides.

关 键 词：Scale-up _(L)-Cbz-LysNCA α-Poly(_(L)-lysine) Easy operation 

分 类 号：O62[理学—有机化学]