Addressable DNA Information Processing System with a Fluorescent Readout for Rewritable Memory  

作　　者：Zirui Xi Mengyao Yang Yuqiang Hu Tongbo Wu 

机构地区：[1]School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430030 China

出　　处：《Chinese Journal of Chemistry》2023年第20期2628-2634,共7页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.82172372 and 21904045).

摘　　要：DNA-based nanostructure allows the construction of molecular devices useful in biological computing and information processing.Herein,an addressable and editable DNA information processing system established on a fluorescence intensity signal detection platform to save and encrypt information is proposed.The system operates by encoding information into distinct and changeable units of the trigger strands decoding by fluorescence intensity signal detection.Through toehold-mediated strand displacement reactions,the trigger strand can be precisely added to and removed from the memorizer and reporter to implement the function of editing,encrypting,and decrypting.Our strategy is simple to implement,requiring only two mixing steps at room temperature for each operation and fluorescence intensity signal detection to read the data.And the system can realize accurate retrieval of specific individual information,eliminating all unnecessary redundant readouts.Because of its point-to-point accurate readout and programmability,the system is expected to become a powerful tool for the future development of information storage and sensing of biological molecules.

关 键 词：Information processing Strand displacement SELF-ASSEMBLY FLUORESCENCE DNA structures 

分 类 号：O57[理学—粒子物理与原子核物理]