淫羊藿及其制剂主要化学成分与肝损伤作用研究进展  

Research progress on main chemical constituents and liver injury effects of Epimedii Folium and its preparations

作　　者：张悦[1] 王佳艺 刘慧敏 殷宏庆 宋丽丽[1] 李遇伯[1] ZHANG Yue;WANG Jia-yi;LIU Hui-min;YIN Hong-qing;SONG Li-li;LI Yu-bo(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中药学院,天津301617

出　　处：《中草药》2023年第21期7213-7221,共9页Chinese Traditional and Herbal Drugs

基　　金：国家中医药管理局青年岐黄学者支持项目。

摘　　要：近年来,由中药或中药复方制剂引发的肝损伤问题频发。淫羊藿及其复方制剂壮骨关节丸、仙灵骨葆胶囊被发现具有引起肝损伤的风险,通过对淫羊藿及其2种制剂的化学成分进行归纳总结,以淫羊藿及其复方制剂的肝毒性研究为中心,深度剖析淫羊藿相关肝毒性形成原因及风险因素,为科学评价淫羊藿及其制剂的安全性,实现淫羊藿毒性的全面防控奠定理论基础,保证淫羊藿临床用药的安全性。In recent years,there has been an increasing occurrence of liver injury caused by traditional Chinese medicine or complex formulations of traditional Chinese medicine.Studies have identified a risk of liver injury associated with the herb Yinyanghuo(Epimedii Folium)and its complex preparations such as Zhuanggu Guanjie Pills(壮骨关节丸)and Xianling Gubao Capsule(仙灵骨葆胶囊).By summarizing the chemical components of Epimedii Folium and these two preparations,this research aims to analyze the hepatotoxicity of Epimedii Folium and its complex preparations,and investigate the underlying causes and risk factors.The goal is to establish a theoretical basis for the comprehensive prevention and control of Epimedii Folium toxicity and ensure the safety of its clinical use.

关 键 词：淫羊藿 制剂 肝损伤 壮骨关节丸 仙灵骨葆胶囊 2″-鼠李糖基淫羊藿次苷Ⅱ 宝藿苷Ⅰ 宝藿苷Ⅱ 箭藿苷A 淫羊藿素 淫羊藿次苷Ⅰ 

分 类 号：R285[医药卫生—中药学]